The Rise and Fall of Otosclerosis: A Population-based Study of Disease Incidence Spanning 70 Years.
Otol Neurotol
; 41(9): e1082-e1090, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32925838
ABSTRACT
OBJECTIVE:
Although it is commonly held that otosclerosis has become increasingly uncommon over recent decades, no population-based data exist to characterize this trend. Moreover, because most large epidemiologic databases within the United States primarily include cancer data, even the modern incidence of otosclerosis is unknown. The chief objective of the current work was to characterize the trend in the incidence of otosclerosis over 70 years using the unique resources of the Rochester Epidemiology Project. STUDYDESIGN:
Population-based study. PATIENTS Residents of Olmsted County, Minnesota diagnosed with otosclerosis. MAIN OUTCOMEMEASURE:
Disease incidence from 1950 to 2017.RESULTS:
From 1950 to 2017, 614 incident cases of otosclerosis were identified. The incidence rose from 8.9 per 100,000 person-years in the 1950s to a peak of 18.5 from 1970 to 1974. From this peak, the incidence significantly declined to 6.2 per 100,000 person-years by the early-1990s and reached a nadir of 3.2 from 2015 to 2017 (p<0.001). From 1970 to 2017, age at diagnosis (pâ=â0.23) and the proportion of bilateral cases (pâ=â0.16) did not significantly change; pure-tone average at diagnosis did not clinically appreciably change over the study period (median difference <5âdB across decades, pâ=â0.034).CONCLUSIONS:
The incidence of otosclerosis drastically declined since the early-1970s. Historically considered one of the most common causes of acquired hearing loss, the low modern incidence of otosclerosis renders it legally a "rare disease" within the United States. These trends require consideration when determining trainee case requirements and developing practice guidelines.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Otosclerose
Tipo de estudo:
Guideline
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Otol Neurotol
Assunto da revista:
NEUROLOGIA
/
OTORRINOLARINGOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article