PARP-1 Flips the Epigenetic Switch on Obesity.

Margulies, Carla E; Ladurner, Andreas G

Margulies, Carla E; Ladurner, Andreas G.

Afiliação

Margulies CE; Biomedical Center, Department of Molecular Biology, Ludwig-Maximilians-University Munich, Grosshaderner Strasse 9, 82152 Planegg, Germany.
Ladurner AG; Biomedical Center, Department of Physiological Chemistry, Ludwig-Maximilians-University Munich, Grosshaderner Strasse 9, 82152 Planegg, Germany; Eisbach Bio GmbH, Am Klopferspitz 19, 82152 Planegg, Germany. Electronic address: andreas.ladurner@bmc.med.lmu.de.

Mol Cell ; 79(6): 874-875, 2020 09 17.

Article em En | MEDLINE | ID: mdl-32946760

RESUMO

PARP enzymes are increasingly taking on important roles beyond DNA repair. Huang et al. (2020b) report how the NAD+-dependent ADP-ribosylation of histone H2B by PARP-1 in complex with a metabolic enzyme suppresses the phosphorylation of an adjacent residue, impacting adipogenesis.

Assuntos

Histonas; Inibidores de Poli(ADP-Ribose) Polimerases; ADP-Ribosilação; Adipogenia; Epigênese Genética; Humanos; Obesidade; Fosforilação; Poli(ADP-Ribose) Polimerases

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Histonas / Inibidores de Poli(ADP-Ribose) Polimerases Limite: Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha

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