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Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma.
Dong, Rui; Yang, Ran; Zhan, Yong; Lai, Hua-Dong; Ye, Chun-Jing; Yao, Xiao-Ying; Luo, Wen-Qin; Cheng, Xiao-Mu; Miao, Ju-Ju; Wang, Jun-Feng; Liu, Bai-Hui; Liu, Xiang-Qi; Xie, Lu-Lu; Li, Yi; Zhang, Man; Chen, Lian; Song, Wei-Chen; Qian, Wei; Gao, Wei-Qiang; Tang, Yun-Hui; Shen, Chun-Yan; Jiang, Wei; Chen, Gong; Yao, Wei; Dong, Kui-Ran; Xiao, Xian-Min; Zheng, Shan; Li, Kai; Wang, Jia.
Afiliação
  • Dong R; Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China. Electronic address: rdong@fudan.edu.cn.
  • Yang R; Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
  • Zhan Y; Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
  • Lai HD; School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China.
  • Ye CJ; Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
  • Yao XY; Family Planning Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China.
  • Luo WQ; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
  • Cheng XM; School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China.
  • Miao JJ; School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China.
  • Wang JF; Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
  • Liu BH; Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
  • Liu XQ; Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
  • Xie LL; Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
  • Li Y; Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
  • Zhang M; School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China.
  • Chen L; Department of Pathology, Children's Hospital of Fudan University, Shanghai 201102, China.
  • Song WC; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
  • Qian W; School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China.
  • Gao WQ; School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 20
  • Tang YH; Family Planning Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China.
  • Shen CY; Family Planning Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China.
  • Jiang W; Genergy Bio-technology (Shanghai) Co., Ltd, Shanghai 200235, China.
  • Chen G; Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
  • Yao W; Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
  • Dong KR; Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
  • Xiao XM; Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
  • Zheng S; Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
  • Li K; Department of Pediatric Surgery, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China. Electronic address: likai2727@163.com.
  • Wang J; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address: wj860520@163.com.
Cancer Cell ; 38(5): 716-733.e6, 2020 11 09.
Article em En | MEDLINE | ID: mdl-32946775
ABSTRACT
Neuroblastoma (NB), which is a subtype of neural-crest-derived malignancy, is the most common extracranial solid tumor occurring in childhood. Despite extensive research, the underlying developmental origin of NB remains unclear. Using single-cell RNA sequencing, we generate transcriptomes of adrenal NB from 160,910 cells of 16 patients and transcriptomes of putative developmental cells of origin of NB from 12,103 cells of early human embryos and fetal adrenal glands at relatively late development stages. We find that most adrenal NB tumor cells transcriptionally mirror noradrenergic chromaffin cells. Malignant states also recapitulate the proliferation/differentiation status of chromaffin cells in the process of normal development. Our findings provide insight into developmental trajectories and cellular states underlying human initiation and progression of NB.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Suprarrenais / Glândulas Suprarrenais / Perfilação da Expressão Gênica / Análise de Célula Única / Neuroblastoma Limite: Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Suprarrenais / Glândulas Suprarrenais / Perfilação da Expressão Gênica / Análise de Célula Única / Neuroblastoma Limite: Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article