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Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients.
Lang, Peter; Eichholz, Thomas; Bakchoul, Tamam; Streiter, Monika; Petrasch, Maurice; Bösmüller, Hans; Klein, Reinhild; Rabsteyn, Armin; Lang, Anne-Marie; Adams, Constantin; Klingel, Karin; Gessner, Michaela; Rosenberger, Peter; Ruef, Peter; Handgretinger, Rupert.
Afiliação
  • Lang P; Children's University Hospital, Eberhard Karls University Tuebingen, Tuebingen, Germany.
  • Eichholz T; Children's University Hospital, Eberhard Karls University Tuebingen, Tuebingen, Germany.
  • Bakchoul T; Institute of Transfusion Medicine, Eberhard Karls University Tuebingen, Tuebingen, Germany.
  • Streiter M; Children's Hospital, SLK-Kliniken Heilbronn GmbH, Heilbronn, Germany.
  • Petrasch M; Children's Hospital, SLK-Kliniken Heilbronn GmbH, Heilbronn, Germany.
  • Bösmüller H; Institute of Pathology, Eberhard Karls University Tuebingen, Tuebingen, Germany.
  • Klein R; Department of Haematology/Oncology, Eberhard Karls University Tuebingen, Tuebingen, Germany.
  • Rabsteyn A; Children's University Hospital, Eberhard Karls University Tuebingen, Tuebingen, Germany.
  • Lang AM; Children's University Hospital, Eberhard Karls University Tuebingen, Tuebingen, Germany.
  • Adams C; Children's University Hospital, Eberhard Karls University Tuebingen, Tuebingen, Germany.
  • Klingel K; Institute of Pathology, Eberhard Karls University Tuebingen, Tuebingen, Germany.
  • Gessner M; Children's University Hospital, Eberhard Karls University Tuebingen, Tuebingen, Germany.
  • Rosenberger P; University Hospital for Intensive Care and Anaesthesiology, Eberhard Karls University Tuebingen, Tuebingen, Germany.
  • Ruef P; Children's Hospital, SLK-Kliniken Heilbronn GmbH, Heilbronn, Germany.
  • Handgretinger R; Children's University Hospital, Eberhard Karls University Tuebingen, Tuebingen, Germany.
J Pediatric Infect Dis Soc ; 9(5): 622-625, 2020 Nov 10.
Article em En | MEDLINE | ID: mdl-32951037
The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, we treated 2 patients with defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved during treatment. Moreover, coagulation parameters indicating hypofibrinolysis and complement activation normalized. The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, 2 patients received defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved and hypofibrinolysis/complement activation normalized during treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Polidesoxirribonucleotídeos / Inibidores da Agregação Plaquetária / Infecções por Coronavirus / Síndrome de Resposta Inflamatória Sistêmica Tipo de estudo: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans Idioma: En Revista: J Pediatric Infect Dis Soc Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Polidesoxirribonucleotídeos / Inibidores da Agregação Plaquetária / Infecções por Coronavirus / Síndrome de Resposta Inflamatória Sistêmica Tipo de estudo: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans Idioma: En Revista: J Pediatric Infect Dis Soc Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha