Exploring the mechanism of cisplatin resistance by transcriptome sequencing and reversing the chemoresistance by autophagy inhibition in small cell lung cancer.

Ma, Kaiyan; Li, Shuxin; Huo, Xueyun; Guo, Meng; Du, Xiaoyan; Li, Changlong; Liu, Xin; Lv, Jianyi; Chen, Zhenwen

Ma, Kaiyan; Li, Shuxin; Huo, Xueyun; Guo, Meng; Du, Xiaoyan; Li, Changlong; Liu, Xin; Lv, Jianyi; Chen, Zhenwen.

Afiliação

Ma K; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, PR China.
Li S; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, PR China.
Huo X; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, PR China; Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, 100069, PR China.
Guo M; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, PR China; Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, 100069, PR China.
Du X; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, PR China; Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, 100069, PR China.
Li C; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, PR China; Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, 100069, PR China.
Liu X; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, PR China; Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, 100069, PR China.
Lv J; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, PR China; Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, 100069, PR China. Electronic address: susanvalid@ccmu.edu.cn.
Chen Z; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, PR China; Beijing Key Laboratory of Cancer Invasion & Metastasis Research, Beijing, 100069, PR China. Electronic address: czwen@ccmu.edu.cn.

Biochem Biophys Res Commun ; 533(3): 474-480, 2020 12 10.

Article em En | MEDLINE | ID: mdl-32977950

Assuntos

Antineoplásicos/farmacologia; Cisplatino/farmacologia; Neoplasias Pulmonares/metabolismo; Carcinoma de Pequenas Células do Pulmão/metabolismo; Antimaláricos/farmacologia; Autofagia/efeitos dos fármacos; Linhagem Celular Tumoral; Resistencia a Medicamentos Antineoplásicos; Perfilação da Expressão Gênica; Humanos; Neoplasias Pulmonares/genética; Análise de Sequência de RNA; Carcinoma de Pequenas Células do Pulmão/genética; Ubiquitinação

Palavras-chave

Autophagy; Cisplatin; Resistance; Small cell lung cancer; Transcriptome sequencing; Ubiquitination

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cisplatino / Carcinoma de Pequenas Células do Pulmão / Neoplasias Pulmonares / Antineoplásicos Limite: Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2020 Tipo de documento: Article

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