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Adipocytes fail to maintain cellular identity during obesity due to reduced PPARγ activity and elevated TGFß-SMAD signaling.
Roh, Hyun Cheol; Kumari, Manju; Taleb, Solaema; Tenen, Danielle; Jacobs, Christopher; Lyubetskaya, Anna; Tsai, Linus T-Y; Rosen, Evan D.
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  • Roh HC; Division of Endocrinology, Diabetes and Obesity, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA; Broad Institute, Cambridge, MA, 02142, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. Electronic address: hyunro
  • Kumari M; Division of Endocrinology, Diabetes and Obesity, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.
  • Taleb S; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
  • Tenen D; Division of Endocrinology, Diabetes and Obesity, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA; Broad Institute, Cambridge, MA, 02142, USA.
  • Jacobs C; Division of Endocrinology, Diabetes and Obesity, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA; Broad Institute, Cambridge, MA, 02142, USA.
  • Lyubetskaya A; Division of Endocrinology, Diabetes and Obesity, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA; Broad Institute, Cambridge, MA, 02142, USA.
  • Tsai LT; Division of Endocrinology, Diabetes and Obesity, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA; Broad Institute, Cambridge, MA, 02142, USA.
  • Rosen ED; Division of Endocrinology, Diabetes and Obesity, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA; Broad Institute, Cambridge, MA, 02142, USA. Electronic address: erosen@bidmc.harvard.edu.
Mol Metab ; 42: 101086, 2020 12.
Article em En | MEDLINE | ID: mdl-32992037
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adipócitos / PPAR gama / Obesidade Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Metab Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adipócitos / PPAR gama / Obesidade Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Metab Ano de publicação: 2020 Tipo de documento: Article