Suppressed ER-associated degradation by intraglomerular cross talk between mesangial cells and podocytes causes podocyte injury in diabetic kidney disease.

Fujimoto, Daisuke; Kuwabara, Takashige; Hata, Yusuke; Umemoto, Shuro; Kanki, Tomoko; Nishiguchi, Yoshihiko; Mizumoto, Teruhiko; Hayata, Manabu; Kakizoe, Yutaka; Izumi, Yuichiro; Takahashi, Satoru; Mukoyama, Masashi

Fujimoto, Daisuke; Kuwabara, Takashige; Hata, Yusuke; Umemoto, Shuro; Kanki, Tomoko; Nishiguchi, Yoshihiko; Mizumoto, Teruhiko; Hayata, Manabu; Kakizoe, Yutaka; Izumi, Yuichiro; Takahashi, Satoru; Mukoyama, Masashi.

Afiliação

Fujimoto D; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Kuwabara T; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Hata Y; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Umemoto S; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Kanki T; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Nishiguchi Y; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Mizumoto T; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Hayata M; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Kakizoe Y; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Izumi Y; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Takahashi S; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Mukoyama M; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.

FASEB J ; 34(11): 15577-15590, 2020 11.

Article em En | MEDLINE | ID: mdl-32996639

Assuntos

Albuminúria/patologia; Apoptose; Diabetes Mellitus Experimental/complicações; Nefropatias Diabéticas/patologia; Degradação Associada com o Retículo Endoplasmático; Células Mesangiais/patologia; Podócitos/patologia; Albuminúria/etiologia; Albuminúria/metabolismo; Animais; Nefropatias Diabéticas/etiologia; Nefropatias Diabéticas/metabolismo; Estresse do Retículo Endoplasmático; Fator de Transcrição MafB/metabolismo; Masculino; Células Mesangiais/metabolismo; Camundongos; Camundongos Obesos; Podócitos/metabolismo; Ratos; Ratos Sprague-Dawley; Transdução de Sinais

Palavras-chave

ERAD; diabetic nephropathy; nephrin phosphorylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Diabetes Mellitus Experimental / Nefropatias Diabéticas / Albuminúria / Células Mesangiais / Podócitos / Degradação Associada com o Retículo Endoplasmático Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão

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