A Dinuclear Persulfide-Bridged Ruthenium Compound is a Hypoxia-Selective Hydrogen Sulfide (H2 S) Donor.
Angew Chem Int Ed Engl
; 60(3): 1588-1592, 2021 01 18.
Article
em En
| MEDLINE
| ID: mdl-33022823
ABSTRACT
Hydrogen sulfide (H2 S) is a gaseous molecule that has received attention for its role in biological processes and therapeutic potential in diseases, such as ischemic reperfusion injury. Despite its clinical relevance, delivery of H2 S to biological systems is hampered by its toxicity at high concentrations. Herein, we report the first metal-based H2 S donor that delivers this gas selectively to hypoxic cells. We further show that H2 S release from this compound protects H9c2 rat cardiomyoblasts from an in vitro model of ischemic reperfusion injury. These results validate the utility of redox-activated metal complexes as hypoxia-selective H2 S-releasing agents for use as tools to study the role of this gaseous molecule in complex biological systems.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rutênio
/
Sulfetos
/
Complexos de Coordenação
/
Sulfeto de Hidrogênio
/
Hipóxia
Limite:
Animals
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos