CXCR3A promotes the secretion of the antifibrotic decoy receptor sIL-13R&#945;2 by pulmonary fibroblasts.

Worrell, Julie C; Walsh, Sinead M; Fabre, Aurélie; Kane, Rosemary; Hinz, Boris; Keane, Michael P

CXCR3A promotes the secretion of the antifibrotic decoy receptor sIL-13Rα2 by pulmonary fibroblasts.

Worrell, Julie C; Walsh, Sinead M; Fabre, Aurélie; Kane, Rosemary; Hinz, Boris; Keane, Michael P.

Afiliação

Worrell JC; St. Vincent's University Hospital and School of Medicine, University College Dublin and UCD Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland.
Walsh SM; St. Vincent's University Hospital and School of Medicine, University College Dublin and UCD Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland.
Fabre A; UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Kane R; St. Vincent's University Hospital and School of Medicine, University College Dublin and UCD Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland.
Hinz B; UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Keane MP; UCD Conway Research Pathology Core Technology, University College Dublin, Dublin, Ireland.

Am J Physiol Cell Physiol ; 319(6): C1059-C1069, 2020 12 01.

Article em En | MEDLINE | ID: mdl-33026833

Assuntos

Matriz Extracelular/metabolismo; Fibroblastos/metabolismo; Subunidade alfa2 de Receptor de Interleucina-13/metabolismo; Fibrose Pulmonar/patologia; Receptores CXCR3/metabolismo; Células 3T3; Animais; Linhagem Celular; Movimento Celular/fisiologia; Proliferação de Células/fisiologia; Feminino; Interleucina-13/genética; Interleucina-13/metabolismo; Subunidade alfa2 de Receptor de Interleucina-13/genética; Pulmão/citologia; Pulmão/metabolismo; Macrófagos Alveolares/imunologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Proteína Quinase 1 Ativada por Mitógeno/metabolismo; Proteína Quinase 3 Ativada por Mitógeno/metabolismo; Fator de Transcrição RelA/metabolismo

Palavras-chave

CXCR3A; collagen; contractility; fibroblast; fibrosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar / Matriz Extracelular / Subunidade alfa2 de Receptor de Interleucina-13 / Receptores CXCR3 / Fibroblastos Limite: Animals Idioma: En Revista: Am J Physiol Cell Physiol Assunto da revista: FISIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Irlanda

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