Calreticulin promotes EMT in pancreatic cancer via mediating Ca<sup>2+</sup> dependent acute and chronic endoplasmic reticulum stress.

Sheng, Weiwei; Wang, Guosen; Tang, Jingtong; Shi, Xiaoyang; Cao, Rongxian; Sun, Jian; Lin, Yi Heng; Jia, Chao; Chen, Chuanping; Zhou, Jianping; Dong, Ming

Calreticulin promotes EMT in pancreatic cancer via mediating Ca²⁺ dependent acute and chronic endoplasmic reticulum stress.

Sheng, Weiwei; Wang, Guosen; Tang, Jingtong; Shi, Xiaoyang; Cao, Rongxian; Sun, Jian; Lin, Yi Heng; Jia, Chao; Chen, Chuanping; Zhou, Jianping; Dong, Ming.

Afiliação

Sheng W; Department of Gastrointestinal Surgery, The First Hospital, China Medical University, Shenyang, 110001, Liaoning, China.
Wang G; Department of General Surgery, The First Affliated Hospital, Nanchang University, Nanchang, 330006, Jiangxi, China.
Tang J; Department of Gastrointestinal Surgery, The First Hospital, China Medical University, Shenyang, 110001, Liaoning, China.
Shi X; Department of Gastrointestinal Surgery, The First Hospital, China Medical University, Shenyang, 110001, Liaoning, China.
Cao R; Department of General Surgery, The People's Hospital of Liaoning province, Shenyang, 110034, Liaoning, China.
Sun J; Department of Gastrointestinal Surgery, The First Hospital, China Medical University, Shenyang, 110001, Liaoning, China.
Lin YH; Department of Gastrointestinal Surgery, The First Hospital, China Medical University, Shenyang, 110001, Liaoning, China.
Jia C; Department of Gastrointestinal Surgery, The First Hospital, China Medical University, Shenyang, 110001, Liaoning, China.
Chen C; Department of Clinical Laboratory, The Sixth Peoples' hospital of Shenyang, Shenyang, 110003, Liaoning, China.
Zhou J; Department of Gastrointestinal Surgery, The First Hospital, China Medical University, Shenyang, 110001, Liaoning, China.
Dong M; Department of Gastrointestinal Surgery, The First Hospital, China Medical University, Shenyang, 110001, Liaoning, China. dongming@cmu.edu.cn.

J Exp Clin Cancer Res ; 39(1): 209, 2020 Oct 07.

Article em En | MEDLINE | ID: mdl-33028359

Assuntos

Biomarcadores Tumorais/metabolismo; Cálcio/metabolismo; Calreticulina/metabolismo; Estresse do Retículo Endoplasmático; Transição Epitelial-Mesenquimal; Regulação Neoplásica da Expressão Gênica; Neoplasias Pancreáticas/patologia; Animais; Apoptose; Biomarcadores Tumorais/genética; Calreticulina/genética; Proliferação de Células; Endorribonucleases/genética; Endorribonucleases/metabolismo; Feminino; Humanos; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Pessoa de Meia-Idade; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/metabolismo; Prognóstico; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/metabolismo; Taxa de Sobrevida; Células Tumorais Cultivadas; Proteína 1 de Ligação a X-Box/genética; Proteína 1 de Ligação a X-Box/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Calreticulin; Endoplasmic reticulum stress; Epithelial mesenchymal transition; IRE1α; Intracellular free Ca2 +; Pancreatic cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Cálcio / Calreticulina / Transição Epitelial-Mesenquimal / Estresse do Retículo Endoplasmático Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Exp Clin Cancer Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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