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Sex-related differences in the relationship between ß-amyloid and cognitive trajectories in older adults.
Lindbergh, Cutter A; Casaletto, Kaitlin B; Staffaroni, Adam M; La Joie, Renaud; Iaccarino, Leonardo; Edwards, Lauren; Tsoy, Elena; Elahi, Fanny; Walters, Samantha M; Cotter, Devyn; You, Michelle; Apple, Alexandra C; Asken, Breton; Neuhaus, John; Rexach, Jessica E; Wojta, Kevin J; Rabinovici, Gil; Kramer, Joel H.
Afiliação
  • Lindbergh CA; Memory and Aging Center.
  • Casaletto KB; Memory and Aging Center.
  • Staffaroni AM; Memory and Aging Center.
  • La Joie R; Memory and Aging Center.
  • Iaccarino L; Memory and Aging Center.
  • Edwards L; Memory and Aging Center.
  • Tsoy E; Memory and Aging Center.
  • Elahi F; Memory and Aging Center.
  • Walters SM; Memory and Aging Center.
  • Cotter D; Memory and Aging Center.
  • You M; Memory and Aging Center.
  • Apple AC; Memory and Aging Center.
  • Asken B; Memory and Aging Center.
  • Neuhaus J; Department of Epidemiology and Biostatistics.
  • Rexach JE; Program in Neurogenetics, Department of Neurology.
  • Wojta KJ; Department of Psychiatry.
  • Rabinovici G; Memory and Aging Center.
  • Kramer JH; Memory and Aging Center.
Neuropsychology ; 34(8): 835-850, 2020 Nov.
Article em En | MEDLINE | ID: mdl-33030915
Objective: We aimed to test the hypothesis that elevated neocortical ß-amyloid (Aß), a hallmark feature of Alzheimer's disease (AD), predicts sex-specific cognitive trajectories in clinically normal older adults, with women showing greater risk of decline than men. Method: Florbetapir Aß positron emission tomography (PET) was acquired in 149 clinically normal older adults (52% female, Mage = 74). Participants underwent cognitive testing at baseline and during annual follow-up visits over a timespan of up to 5.14 years. Mixed-effects regression models evaluated whether relations between baseline neocortical Standardized Uptake Value Ratio (SUVR) and composite scores of episodic memory, executive functioning, and processing speed were moderated by sex (male/female) and apolipoprotein E (APOE) status (ε4 carrier/noncarrier). Results: Higher baseline SUVR was associated with longitudinal decline in episodic memory in women (b = -1.32, p < .001) but not men (b = -0.30, p = .28). Female APOE ε4 carriers with elevated SUVR showed particularly precipitous declines in episodic memory (b = -4.33, p < .001) whereas other cognitive domains were spared. SUVR did not predict changes in executive functioning or processing speed, regardless of sex (ps >.63), though there was a main effect of SUVR on processing speed (b = 2.50, p = .003). Conclusions: Clinically normal women with elevated Aß are more vulnerable to episodic memory decline than men. Understanding sex-related differences in AD, particularly in preclinical stages, is crucial for guiding precision medicine approaches to early detection and intervention. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Peptídeos beta-Amiloides / Cognição Tipo de estudo: Prognostic_studies / Screening_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neuropsychology Assunto da revista: NEUROLOGIA / PSICOLOGIA Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Peptídeos beta-Amiloides / Cognição Tipo de estudo: Prognostic_studies / Screening_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neuropsychology Assunto da revista: NEUROLOGIA / PSICOLOGIA Ano de publicação: 2020 Tipo de documento: Article