Astrocytes Protect Human Dopaminergic Neurons from &#945;-Synuclein Accumulation and Propagation.

Tsunemi, Taiji; Ishiguro, Yuta; Yoroisaka, Asako; Valdez, Clarissa; Miyamoto, Kengo; Ishikawa, Keiichi; Saiki, Shinji; Akamatsu, Wado; Hattori, Nobutaka; Krainc, Dimitri

Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation.

Tsunemi, Taiji; Ishiguro, Yuta; Yoroisaka, Asako; Valdez, Clarissa; Miyamoto, Kengo; Ishikawa, Keiichi; Saiki, Shinji; Akamatsu, Wado; Hattori, Nobutaka; Krainc, Dimitri.

Afiliação

Tsunemi T; Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 dkrainc@nm.org t-tsunemi@juntendo.ac.jp.
Ishiguro Y; Department of Neurology, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Yoroisaka A; Department of Neurology, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Valdez C; Department of Neurology, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Miyamoto K; Center for Genomic and Regenerative Medicine, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Ishikawa K; Department of Neurology, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Saiki S; Center for Genomic and Regenerative Medicine, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Akamatsu W; Department of Neurology, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Hattori N; Center for Genomic and Regenerative Medicine, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Krainc D; Department of Neurology, School of Medicine, Juntendo University, Tokyo 113-8421, Japan.

J Neurosci ; 40(45): 8618-8628, 2020 11 04.

Article em En | MEDLINE | ID: mdl-33046546

Assuntos

Astrócitos/fisiologia; Neurônios Dopaminérgicos/fisiologia; alfa-Sinucleína/metabolismo; Adulto; Técnicas de Cocultura; Neurônios Dopaminérgicos/metabolismo; Exossomos/metabolismo; Feminino; Humanos; Células-Tronco Pluripotentes Induzidas; Lisossomos/enzimologia; Lisossomos/metabolismo; Masculino; Neuroglia/metabolismo; Transtornos Parkinsonianos/genética; Transtornos Parkinsonianos/metabolismo; ATPases Translocadoras de Prótons/deficiência; ATPases Translocadoras de Prótons/genética; ATPases Translocadoras de Prótons/metabolismo; Sinucleinopatias/genética; Sinucleinopatias/metabolismo; alfa-Sinucleína/biossíntese

Palavras-chave

KuforRakeb syndrome; Parkinson's disease; astrocyte; α-synuclein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Astrócitos / Alfa-Sinucleína / Neurônios Dopaminérgicos Limite: Adult / Female / Humans / Male Idioma: En Revista: J Neurosci Ano de publicação: 2020 Tipo de documento: Article

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