Total Synthesis of Semaglutide Based on a Soluble Hydrophobic-Support-Assisted Liquid-Phase Synthetic Method.
ACS Comb Sci
; 22(12): 821-825, 2020 12 14.
Article
em En
| MEDLINE
| ID: mdl-33058727
ABSTRACT
Considering the high cost of the production of semaglutide, which is currently the most promising antidiabetic drug especially for the treatment of type 2 diabetes mellitus, a new synthetic route of semaglutide production that possesses excellent yield and high purity is of vital importance. Herein, we reported a newly developed synthetic route of semaglutide that is simple and efficient, based on a soluble hydrophobic-support-assisted liquid-phase synthetic method by applying Alloc-chemistry to the synthesis of the main chain peptide and side chain peptide of semaglutide. With careful optimization of the reaction conditions and innovative strategy of post-synthetic treatments, the total yield and purity of the crude semaglutide was improved satisfactorily.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Semelhantes ao Glucagon
/
Hipoglicemiantes
/
Lipídeos
Limite:
Humans
Idioma:
En
Revista:
ACS Comb Sci
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China