Intravenously injected lidocaine or magnesium improves the quality of early recovery after laparoscopic cholecystectomy: A randomised controlled trial.
Eur J Anaesthesiol
; 38(Suppl 1): S1-S8, 2021 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-33074940
ABSTRACT
BACKGROUND:
Previous data show that lidocaine or magnesium has unique characteristics of stress inhibition and antiinflammation.OBJECTIVE:
We aimed to observe the effects of lidocaine or magnesium on the quality of recovery (QoR) after laparoscopic cholecystectomy.DESIGN:
Single-centre, prospective, randomised, double-blind study.SETTING:
The Affiliated Hospital of Xuzhou Medical University from March 2019 to October 2019. PATIENTS One hundred and fourteen patients scheduled for laparoscopic cholecystectomy. INTERVENTION The enrolled patients were randomly divided into three groups. Lidocaine (group L), magnesium sulphate (group M) or 0.9% saline (group C) was administered intravenously 10âmin before induction. MAIN OUTCOMEMEASURES:
The quality of recovery 15 (QoR-15) score, the Hospital Anxiety and Depression Scale (HADS), and the Numerical Rating Scale (NRS) score were selected. The usage of propofol and remifentanil, haemodynamic parameters, anaesthesia recovery parameters and adverse events were also evaluated.RESULTS:
The QoR-15 scores for group L (132.0) and group M (134.0) were 6 and 8 points higher than that of group C (126.0) on POD1 (postoperative day 1) (adjPâ<â0.05). However, the decrease of QoR-15 in Group L is less than the minimal clinically important difference (8).The NRS scores on POD1 in group C 3, were higher than other two groups (adjPâ<â0.05). The dosage of remifentanil in group L was lower than other two groups (adjPâ<â0.05).The physical independence of group L and group M and physical comfort of group M were improved compared with group C.CONCLUSION:
The results show that magnesium sulphate improved the QoR through improving physical comfort and physical independence in patients after laparoscopic cholecystectomy. However, lidocaine had limited effects on QoR under current conditions. TRIAL REGISTRATION ChiCTR1800019092 (www.chictr.org.cn). CLINICAL TRIAL NUMBER AND REGISTRY URL The study was registered in the Chinese Clinical Trials Register (ChiCTR1800019092) https//www.chictr.org.cn.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propofol
/
Colecistectomia Laparoscópica
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Humans
Idioma:
En
Revista:
Eur J Anaesthesiol
Assunto da revista:
ANESTESIOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article