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Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase.
McDonald, Gabrielle; Chubukov, Victor; Coco, John; Truskowski, Kevin; Narayanaswamy, Rohini; Choe, Sung; Steadman, Mya; Artin, Erin; Padyana, Anil K; Jin, Lei; Ronseaux, Sebastien; Locuson, Charles; Fan, Zi-Peng; Erdmann, Tabea; Mann, Alan; Hayes, Sebastian; Fletcher, Mark; Nellore, Kavitha; Rao, Siva Sanjeeva; Subramanya, Hosahalli; Reddy, K Satish; Panigrahi, Sunil K; Antony, Thomas; Gopinath, Sreevalsam; Sui, Zhihua; Nagaraja, Nelamangala; Dang, Lenny; Lenz, Georg; Hurov, Jonathan; Biller, Scott A; Murtie, Josh; Marks, Kevin M; Ulanet, Danielle B.
Afiliação
  • McDonald G; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts. dulanet@reparerx.com Gabrielle.McDonald@agios.com.
  • Chubukov V; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Coco J; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Truskowski K; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Narayanaswamy R; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Choe S; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Steadman M; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Artin E; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Padyana AK; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Jin L; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Ronseaux S; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Locuson C; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Fan ZP; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Erdmann T; Department of Medicine A for Hematology, Oncology, and Pneumology, Universitätsklinikum Münster, Münster, Germany.
  • Mann A; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Hayes S; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Fletcher M; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Nellore K; Aurigene Discovery Technologies Ltd., Bangalore, India.
  • Rao SS; Firmus Laboratories, Hyderabad, India.
  • Subramanya H; Aurigene Discovery Technologies Ltd., Bangalore, India.
  • Reddy KS; GVK Biosciences, Inc.
  • Panigrahi SK; Aurigene Discovery Technologies Ltd., Bangalore, India.
  • Antony T; Aurigene Discovery Technologies Ltd., Bangalore, India.
  • Gopinath S; Aurigene Discovery Technologies Ltd., Bangalore, India.
  • Sui Z; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Nagaraja N; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Dang L; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Lenz G; Department of Medicine A for Hematology, Oncology, and Pneumology, Universitätsklinikum Münster, Münster, Germany.
  • Hurov J; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Biller SA; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Murtie J; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Marks KM; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts.
  • Ulanet DB; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts. dulanet@reparerx.com Gabrielle.McDonald@agios.com.
Mol Cancer Ther ; 19(12): 2502-2515, 2020 12.
Article em En | MEDLINE | ID: mdl-33082276
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Neoplasias Hematológicas / Oxirredutases atuantes sobre Doadores de Grupo CH-CH / Inibidores Enzimáticos / Antineoplásicos Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Mol Cancer Ther Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Neoplasias Hematológicas / Oxirredutases atuantes sobre Doadores de Grupo CH-CH / Inibidores Enzimáticos / Antineoplásicos Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Mol Cancer Ther Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2020 Tipo de documento: Article