Tivozanib mediated inhibition of c-Kit/SCF signaling on Tregs and MDSCs and reversal of tumor induced immune suppression correlates with survival of HCC patients.

Kalathil, Suresh Gopi; Wang, Katy; Hutson, Alan; Iyer, Renuka; Thanavala, Yasmin

Kalathil, Suresh Gopi; Wang, Katy; Hutson, Alan; Iyer, Renuka; Thanavala, Yasmin.

Afiliação

Kalathil SG; Department of Immunology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, USA.
Wang K; Department of Biostatistics & Bioinformatics Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, USA.
Hutson A; Department of Biostatistics & Bioinformatics Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, USA.
Iyer R; Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, USA.
Thanavala Y; Department of Immunology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, USA.

Oncoimmunology ; 9(1): 1824863, 2020 09 30.

Article em En | MEDLINE | ID: mdl-33101775

Assuntos

Carcinoma Hepatocelular; Neoplasias Hepáticas; Células Supressoras Mieloides; Quinolinas; Humanos; Compostos de Fenilureia; Quinolinas/farmacologia

Palavras-chave

HCC; MDSC; Tivozanib; Tregs; c-Kit/SCF; survival

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Carcinoma Hepatocelular / Células Supressoras Mieloides / Neoplasias Hepáticas Limite: Humans Idioma: En Revista: Oncoimmunology Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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