[In vitro models for deciphering the mechanisms underlying the sexual transmission of viruses at the mucosal level]. / Comprendre les mécanismes de transmission sexuelle des virus : apports et limites des modèles in vitro.
Virologie (Montrouge)
; 22(1): 9-26, 2018 02 01.
Article
em Fr
| MEDLINE
| ID: mdl-33111670
ABSTRACT
Sexually transmitted viruses infect the genital and colorectal mucosa of the partner exposed to contaminated genital secretions through a wide range of mechanisms, dictated in part by the organization of the mucosa. Because understanding the modes of entry into the organism of viruses transmitted through sexual intercourse is a necessary prerequisite to the design of treatments to block those infections, in vitro modeling of the transmission is essential. The aim of this review is to present the models and methodologies available for in vitro study of interactions between viruses and mucosal tissue and for preclinical evaluation of antiviral compounds, and to point out their advantages and limitations according to the question being studied.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
Fr
Revista:
Virologie (Montrouge)
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
França