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An Animal Able To Tolerate D2 O.
de Carli, Gabriel José; Contiliani, Danyel Fernandes; Giuliatti, Silvana; Pereira, Tiago Campos.
Afiliação
  • de Carli GJ; Department of Biology, University of Sao Paulo, Av. Bandeirantes, 3900, Ribeirao Preto, Brazil.
  • Contiliani DF; Graduate Program of Genetics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes, 3900, Ribeirao Preto, Brazil.
  • Giuliatti S; Department of Biology, University of Sao Paulo, Av. Bandeirantes, 3900, Ribeirao Preto, Brazil.
  • Pereira TC; Graduate Program of Genetics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes, 3900, Ribeirao Preto, Brazil.
Chembiochem ; 22(6): 988-991, 2021 03 16.
Article em En | MEDLINE | ID: mdl-33125805
It is possible to gain a deeper insight into the role of water in biology by using physicochemical variant molecules, such as deuterium oxide (D2 O); however, D2 O is toxic to multicellular organisms in high concentrations. By using a unique desiccation-rehydration process, we demonstrate that the anhydrobiotic nematode Panagrolaimus superbus is able to tolerate and proliferate in 99 % D2 O. Moreover, we analysed P. superbus' water-channel protein (aquaporin; AQP), which is associated with dehydration/rehydration, by comparing its primary structure and modelling its tertiary structure in silico. Our data evidence that P. superbus' AQP is an aquaglyceroporin, a class of water channel known to display a wider pore; this helps to explain the rapid and successful organismal influx of D2 O into this species. This is the first demonstration of an animal able to withstand high D2 O levels, thus paving a way for the investigation of the effects D2 O on higher levels of biological organization.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óxido de Deutério / Nematoides Limite: Animals / Humans Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óxido de Deutério / Nematoides Limite: Animals / Humans Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil