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L-Arginine Supplementation Improves Vascular Endothelial Dysfunction Induced by High-Fat Diet in Rats Exposed to Hypoxia.
Zhao, Yan-Xia; Tong, Li; Zhang, Guang-Mei; Zhao, Xie-Hui; Sa, Yu-Ping; Liu, Yan; Lu, Dian-Xiang; Ga, Qin; Wu, Ping.
Afiliação
  • Zhao YX; Department of Traditional Chinese Medicine, Qinghai University Medical College, Qinghai, China.
  • Tong L; Department of Traditional Chinese Medicine, Qinghai University Medical College, Qinghai, China.
  • Zhang GM; Department of Traditional Chinese Medicine, Qinghai University Medical College, Qinghai, China.
  • Zhao XH; Department of Traditional Chinese Medicine, Qinghai University Medical College, Qinghai, China.
  • Sa YP; Department of Traditional Chinese Medicine, Qinghai University Medical College, Qinghai, China.
  • Liu Y; Department of Traditional Chinese Medicine, Qinghai University Medical College, Qinghai, China.
  • Lu DX; Department of Traditional Chinese Medicine, Qinghai University Medical College, Qinghai, China.
  • Ga Q; Research Center for High Altitude Medical Sciences, Qinghai University Medical College, Qinghai, China.
  • Wu P; Department of Traditional Chinese Medicine, Qinghai University Medical College, Qinghai, China. Electronic address: wupingyixue@163.com.
Wilderness Environ Med ; 31(4): 400-406, 2020 Dec.
Article em En | MEDLINE | ID: mdl-33132032
INTRODUCTION: Our previous study showed that high-fat diet inhibited the increase in nitric oxide and endothelial nitric oxide synthase expression in the aortic endothelium of rats exposed to hypoxia, and hypoxia plus a high-fat diet led to earlier and more severe vascular endothelial dysfunction (VED) than hypoxia alone. The purpose of the present study was to investigate the effects of L-arginine on high-fat diet-induced VED of rats in hypoxia. METHODS: Forty male Sprague-Dawley rats were randomly divided into 4 groups and treated with hypoxia (H group), hypoxia plus high-fat diet (H+HFD group), hypoxia plus L-arginine (H+L-Arg group), and hypoxia plus high-fat diet and L-arginine (H+HFD+L-Arg group) for 1 wk. Hypoxia was simulated in a hypobaric chamber with an altitude of 5000 m. Aortic morphology and endothelium-dependent vasorelaxation were used to assess VED. RESULTS: High-fat diet impaired vascular remodeling and reduced endothelium-dependent vasodilator response to acetylcholine in rats exposed to hypoxia, secondary to dysregulation of the nitric oxide pathway. L-arginine supplementation significantly increased plasma nitrates and nitrites and endothelial nitric oxide synthase mRNA levels and improved ultrastructural changes in aortic endothelium and endothelium-dependent vasodilator response. CONCLUSIONS: L-arginine prevents aortic ultrastructural changes and reverses VED induced by high-fat diet in rats exposed to hypoxia, which may have implications for VED induced by high-fat diet in high altitude dwellers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta / Arginina / Endotélio Vascular / Dieta Hiperlipídica Limite: Animals Idioma: En Revista: Wilderness Environ Med Assunto da revista: SAUDE AMBIENTAL Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta / Arginina / Endotélio Vascular / Dieta Hiperlipídica Limite: Animals Idioma: En Revista: Wilderness Environ Med Assunto da revista: SAUDE AMBIENTAL Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China