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Macular Corneal Dystrophy: An Updated Review.
Singh, Shalini; Das, Sujata; Kannabiran, Chitra; Jakati, Saumya; Chaurasia, Sunita.
Afiliação
  • Singh S; Cornea and Anterior Segment Services, LVPEI, Hyderabad, India.
  • Das S; Cornea and Anterior Segment Services, LVPEI, Bhubneshwar, India.
  • Kannabiran C; Kallam Anji Reddy Molecular Genetics Laboratory, Prof Brien Holden Eye Research Centre, Hyderabad, India.
  • Jakati S; Ophthalmic Pathology Laboratory, LVPEI, Hyderabad, India.
  • Chaurasia S; Cornea and Anterior Segment Services, LVPEI, Hyderabad, India.
Curr Eye Res ; 46(6): 765-770, 2021 06.
Article em En | MEDLINE | ID: mdl-33171054
Macular Corneal Dystrophy is an autosomal recessive form of corneal dystrophy due to a mutation in CHST6 gene, which results in abnormal proteoglycan synthesis. There is accumulation of abnormal glycosaminoglycans in the corneal stroma and endothelium. The deposition results in progressive loss of corneal transparency and visual acuity. The histopathology shows characteristic alcian blue positive deposits. Management in the cases with visual loss requires keratoplasty either full thickness or lamellar. The decision about the ideal type of keratoplasty depends on age and pre-operative clinical features. Although prognosis after keratoplasty is good, recurrences can occur. Future research should be targeted towards gene therapy in this condition.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Distrofias Hereditárias da Córnea Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Curr Eye Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Distrofias Hereditárias da Córnea Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Curr Eye Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia