Bridging the gap - a new role for STAT3 in TLR4-mediated metabolic reprogramming.

Weiss, Hauke J; O'Neill, Luke Aj

Weiss, Hauke J; O'Neill, Luke Aj.

Afiliação

Weiss HJ; School of Biochemistry and Immunology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin 2, Ireland.
O'Neill LA; School of Biochemistry and Immunology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin 2, Ireland.

Immunol Cell Biol ; 99(2): 122-125, 2021 02.

Article em En | MEDLINE | ID: mdl-33179321

RESUMO

Balic et al. describe a new role for STAT3 in TLR4 signalling in macrophages, linking LPS mediated activation of this innate immune receptor to phosphorylation of mitochondrial STAT3, resulting in distinct metabolic reprogramming.

Assuntos

Lipopolissacarídeos; Receptor 4 Toll-Like; Animais; Macrófagos/metabolismo; Camundongos; Camundongos Knockout; Fator de Transcrição STAT3/metabolismo; Transdução de Sinais; Receptor 4 Toll-Like/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lipopolissacarídeos / Receptor 4 Toll-Like Limite: Animals Idioma: En Revista: Immunol Cell Biol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Irlanda

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