Caspase-3 knockout attenuates radiation-induced tumor repopulation via impairing the ATM/p53/Cox-2/PGE<sub>2</sub> pathway in non-small cell lung cancer.

Zhao, Minghui; Wang, Yiwei; Zhao, Yucui; He, Sijia; Zhao, Ruyi; Song, Yanwei; Cheng, Jin; Gong, Yanping; Xie, Jianzhu; Wang, Yulan; Hu, Binjie; Tian, Ling; Huang, Qian

Caspase-3 knockout attenuates radiation-induced tumor repopulation via impairing the ATM/p53/Cox-2/PGE₂ pathway in non-small cell lung cancer.

Zhao, Minghui; Wang, Yiwei; Zhao, Yucui; He, Sijia; Zhao, Ruyi; Song, Yanwei; Cheng, Jin; Gong, Yanping; Xie, Jianzhu; Wang, Yulan; Hu, Binjie; Tian, Ling; Huang, Qian.

Afiliação

Zhao M; Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Wang Y; Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Zhao Y; Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
He S; Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Zhao R; Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Song Y; Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Cheng J; Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Gong Y; Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Xie J; Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Wang Y; Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Hu B; Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Tian L; Shanghai Key Laboratory for Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Huang Q; Department of Central Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.

Aging (Albany NY) ; 12(21): 21758-21776, 2020 11 07.

Article em En | MEDLINE | ID: mdl-33180744

Assuntos

Carcinoma Pulmonar de Células não Pequenas/patologia; Caspase 3/metabolismo; Neoplasias Pulmonares/patologia; Radiação Ionizante; Animais; Proteínas Mutadas de Ataxia Telangiectasia/metabolismo; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Linhagem Celular Tumoral; Ciclo-Oxigenase 2/metabolismo; Dano ao DNA/fisiologia; Dano ao DNA/efeitos da radiação; Dinoprostona/metabolismo; Técnicas de Inativação de Genes; Xenoenxertos; Humanos; Neoplasias Pulmonares/metabolismo; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Transdução de Sinais/fisiologia; Transdução de Sinais/efeitos da radiação; Proteína Supressora de Tumor p53/metabolismo

Palavras-chave

DNA damage response; caspase-3; non-small cell lung cancer; radiotherapy; tumor repopulation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radiação Ionizante / Carcinoma Pulmonar de Células não Pequenas / Caspase 3 / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Aging (Albany NY) Assunto da revista: GERIATRIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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