Lauric acid ameliorates lipopolysaccharide (LPS)-induced liver inflammation by mediating TLR4/MyD88 pathway in Sprague Dawley (SD) rats.

Khan, Hidayat Ullah; Aamir, Khurram; Jusuf, Patricia Regina; Sethi, Gautam; Sisinthy, Sreenivas Patro; Ghildyal, Reena; Arya, Aditya

Khan, Hidayat Ullah; Aamir, Khurram; Jusuf, Patricia Regina; Sethi, Gautam; Sisinthy, Sreenivas Patro; Ghildyal, Reena; Arya, Aditya.

Afiliação

Khan HU; School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia.
Aamir K; School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia.
Jusuf PR; School of Biosciences, Faculty of Science, The University of Melbourne, Victoria 3010, Australia.
Sethi G; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Sisinthy SP; Faculty of Pharmacy and Health Sciences, University of Kuala Lumpur, Royal College of Medicine Perak, Ipoh 30450, Perak, Malaysia.
Ghildyal R; Centre for Research in Therapeutic Solutions, Faculty of Science and Technology, University of Canberra, Canberra, Australia.
Arya A; School of Biosciences, Faculty of Science, The University of Melbourne, Victoria 3010, Australia; Department of Pharmacology and Therapeutics, School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Malaysia; Department of Pharmacology and Therapeutics, Faculty

Life Sci ; 265: 118750, 2021 Jan 15.

Article em En | MEDLINE | ID: mdl-33188836

Assuntos

Inflamação/tratamento farmacológico; Ácidos Láuricos/farmacologia; Animais; Doença Hepática Induzida por Substâncias e Drogas/metabolismo; Citocinas/metabolismo; Inflamação/patologia; Interleucina-1beta/metabolismo; Interleucina-6/metabolismo; Ácidos Láuricos/metabolismo; Lipopolissacarídeos/farmacologia; Fígado/imunologia; Fígado/metabolismo; Fígado/patologia; Masculino; Fator 88 de Diferenciação Mieloide/metabolismo; NF-kappa B/metabolismo; Ratos; Ratos Sprague-Dawley; Transdução de Sinais; Receptor 4 Toll-Like/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Inflammation; Jess; LPS; Lauric acid; Liver; TLR4

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inflamação / Ácidos Láuricos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Malásia

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