The attentive focus on T cell-mediated autoimmune pathogenesis of psoriasis, lichen planus and vitiligo.
Scand J Immunol
; 93(4): e13000, 2021 Apr.
Article
em En
| MEDLINE
| ID: mdl-33190330
ABSTRACT
T cell-mediated autoimmune skin diseases develop as a result of the aberrant immune response to the skin cells with T cells playing a central role. These chronic inflammatory skin diseases encompass various types including psoriasis, lichen planus and vitiligo. These diseases show similarities in their immune-pathophysiology. In the last decade, immunomodulating agents have been very successful in the management of these diseases thanks to a better understanding of the pathophysiology. In this review, we will discuss the immunopathogenic mechanisms and highlight the role of T lymphocytes in psoriasis, lichen planus and vitiligo. This study could provide new insights into a better understanding of targeted therapeutic pathways and biological therapies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Psoríase
/
Doenças Autoimunes
/
Vitiligo
/
Linfócitos T
/
Líquen Plano
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Scand J Immunol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Irã