Comparative Assessment of Extrapolation Methods Based on the Conventional Free Drug Hypothesis and Plasma Protein-Mediated Hepatic Uptake Theory for the Hepatic Clearance Predictions of Two Drugs Extensively Bound to Both the Albumin And Alpha-1-Acid Glycoprotein.

Bteich, Michel; Poulin, Patrick; Haddad, Sami

Bteich, Michel; Poulin, Patrick; Haddad, Sami.

Afiliação

Bteich M; Department of Environmental and Occupational Health, School of Public Health, Université de Montréal, Montreal, Quebec, Canada; Centre de recherche en santé publique (CReSP), Montreal, Quebec, Canada.
Poulin P; Department of Environmental and Occupational Health, School of Public Health, Université de Montréal, Montreal, Quebec, Canada; Consultant Patrick Poulin Inc., Quebec City, Quebec, Canada.
Haddad S; Department of Environmental and Occupational Health, School of Public Health, Université de Montréal, Montreal, Quebec, Canada; Centre de recherche en santé publique (CReSP), Montreal, Quebec, Canada. Electronic address: sami.haddad@umontreal.ca.

J Pharm Sci ; 110(3): 1385-1391, 2021 03.

Article em En | MEDLINE | ID: mdl-33217427

Assuntos

Orosomucoide; Preparações Farmacêuticas; Albuminas/metabolismo; Animais; Proteínas Sanguíneas/metabolismo; Fígado/metabolismo; Modelos Biológicos; Orosomucoide/metabolismo; Preparações Farmacêuticas/metabolismo; Ligação Proteica; Ratos

Palavras-chave

Albumin; Alpha-1-acid glycoprotein; Fractional binding; Hepatic clearance; IVIVE; PBPK; Quantitative modeling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Orosomucoide / Preparações Farmacêuticas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Pharm Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá

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