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Uncompetitive nanomolar dimeric indenoindole inhibitors of the human breast cancer resistance pump ABCG2.
Guragossian, Nathalie; Belhani, Billel; Moreno, Alexis; Nunes, Magda Teixeira; Gonzalez-Lobato, Lucia; Marminon, Christelle; Berthier, Laurent; Rocio Andrade Pires, Amanda Do; Özvegy-Laczka, Csilla; Sarkadi, Balázs; Terreux, Raphaël; Bouaziz, Zouhair; Berredjem, Malika; Jose, Joachim; Di Pietro, Attilio; Falson, Pierre; Le Borgne, Marc.
Afiliação
  • Guragossian N; EA 4446 Bioactive Molecules and Medicinal Chemistry, Université Claude Bernard Lyon 1, 69373, Lyon, France; Drug Resistance & Membrane Proteins Group - Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-UCBL1 UMR 5086, IBCP, 69367, Lyon, France.
  • Belhani B; EA 4446 Bioactive Molecules and Medicinal Chemistry, Université Claude Bernard Lyon 1, 69373, Lyon, France; Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Badji Mokhtar - Annaba University, 23000, Annaba, Algeria.
  • Moreno A; Drug Resistance & Membrane Proteins Group - Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-UCBL1 UMR 5086, IBCP, 69367, Lyon, France.
  • Nunes MT; Drug Resistance & Membrane Proteins Group - Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-UCBL1 UMR 5086, IBCP, 69367, Lyon, France.
  • Gonzalez-Lobato L; Drug Resistance & Membrane Proteins Group - Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-UCBL1 UMR 5086, IBCP, 69367, Lyon, France.
  • Marminon C; EA 4446 Bioactive Molecules and Medicinal Chemistry, Université Claude Bernard Lyon 1, 69373, Lyon, France; Small Molecules for Biological Targets Team, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, CNRS 5286, INSERM 1052, Université Claude Bernard Lyon 1, Univ Lyon, Lyon, 69373,
  • Berthier L; Laboratoire de Biologie Tissulaire et Ingénierie, CNRS-UCBL1 UMR 5305, IBCP, 69367, Lyon, France.
  • Rocio Andrade Pires AD; Drug Resistance & Membrane Proteins Group - Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-UCBL1 UMR 5086, IBCP, 69367, Lyon, France; Departamento de Bioquímica e Biologia Molecular, Universidade Federal Do Paraná, Curitiba, Brazil.
  • Özvegy-Laczka C; Lnstitute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 1117, Budapest, Hungary.
  • Sarkadi B; Lnstitute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 1117, Budapest, Hungary.
  • Terreux R; Laboratoire de Biologie Tissulaire et Ingénierie, CNRS-UCBL1 UMR 5305, IBCP, 69367, Lyon, France.
  • Bouaziz Z; EA 4446 Bioactive Molecules and Medicinal Chemistry, Université Claude Bernard Lyon 1, 69373, Lyon, France.
  • Berredjem M; Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Badji Mokhtar - Annaba University, 23000, Annaba, Algeria.
  • Jose J; Institut für Pharmazeutische und Medizinische Chemie, PharmaCampus - Westfälische Wilhelms-Universität Münster, D-48149, Münster, Germany.
  • Di Pietro A; Drug Resistance & Membrane Proteins Group - Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-UCBL1 UMR 5086, IBCP, 69367, Lyon, France.
  • Falson P; Drug Resistance & Membrane Proteins Group - Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-UCBL1 UMR 5086, IBCP, 69367, Lyon, France. Electronic address: pierre.falson@univ-lyon1.fr.
  • Le Borgne M; EA 4446 Bioactive Molecules and Medicinal Chemistry, Université Claude Bernard Lyon 1, 69373, Lyon, France; Small Molecules for Biological Targets Team, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, CNRS 5286, INSERM 1052, Université Claude Bernard Lyon 1, Univ Lyon, Lyon, 69373,
Eur J Med Chem ; 211: 113017, 2021 Feb 05.
Article em En | MEDLINE | ID: mdl-33223263
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP / Indóis / Proteínas de Neoplasias / Antineoplásicos Limite: Female / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: França
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP / Indóis / Proteínas de Neoplasias / Antineoplásicos Limite: Female / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: França