Mortality in Yusho patients exposed to polychlorinated biphenyls and polychlorinated dibenzofurans: a 50-year retrospective cohort study.
Environ Health
; 19(1): 119, 2020 11 23.
Article
em En
| MEDLINE
| ID: mdl-33228703
ABSTRACT
BACKGROUND:
In 1968, the Yusho incident resulted in accidental exposure to polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs), and related compounds in Japan. This study updated the risk of mortality in Yusho patients.METHODS:
We obtained updated cohort data for all Yusho patients for the period 1968-2017. We calculated standardized mortality ratios (SMRs) for all-cause and cause-specific mortality over a 50-year follow-up period compared with the general population in Japan.RESULTS:
A total of 1664 Yusho patients with 63,566 person-years of follow up were included in the analysis. Among males, excess mortality was observed for all cancers (SMR 1.22, 95% confidence interval [CI] 1.02 to 1.45) and lung cancer (SMR 1.59, 95% CI 1.12 to 2.19). Among females, increased mortality was observed for liver cancer (SMR 2.05, 95% CI 1.02 to 3.67). No significant increase was seen in non-cancer-related mortality compared with the general population.CONCLUSIONS:
Carcinogenic risk in humans after exposure to PCBs and PCDFs remains higher among Yusho patients. Our findings suggest the importance of care engagement and optimum management to deal with the burden of Yusho disease.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Porfirias
/
Bifenilos Policlorados
/
Poluentes Ambientais
/
Vazamento de Resíduos Químicos
/
Dibenzofuranos Policlorados
/
Exposição Dietética
/
Neoplasias
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Environ Health
Assunto da revista:
SAUDE AMBIENTAL
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Japão