Wide-open conformation of UDP-MurNc-tripeptide ligase revealed by the substrate-free structure of MurE from Acinetobacter baumannii.

Jung, Kyoung Ho; Kim, Yeon-Gil; Kim, Chang Min; Ha, Hyun Ji; Lee, Chang Sup; Lee, Jun Hyuck; Park, Hyun Ho

Wide-open conformation of UDP-MurNc-tripeptide ligase revealed by the substrate-free structure of MurE from Acinetobacter baumannii.

Jung, Kyoung Ho; Kim, Yeon-Gil; Kim, Chang Min; Ha, Hyun Ji; Lee, Chang Sup; Lee, Jun Hyuck; Park, Hyun Ho.

Afiliação

Jung KH; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, Korea.
Kim YG; College of Pharmacy, Chung-Ang University, Seoul, Korea.
Kim CM; Pohang Accelerator Laboratory, Pohang University of Science and Technology, Korea.
Ha HJ; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, Korea.
Lee CS; College of Pharmacy, Chung-Ang University, Seoul, Korea.
Lee JH; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, Korea.
Park HH; College of Pharmacy, Chung-Ang University, Seoul, Korea.

FEBS Lett ; 595(2): 275-283, 2021 01.

Article em En | MEDLINE | ID: mdl-33230844

Assuntos

Acinetobacter baumannii/enzimologia; Peptídeo Sintases/química; Peptídeo Sintases/metabolismo; Acinetobacter baumannii/efeitos dos fármacos; Antibacterianos/química; Antibacterianos/farmacologia; Proteínas de Bactérias/química; Proteínas de Bactérias/metabolismo; Cristalografia por Raios X; Desenho de Fármacos; Modelos Moleculares; Conformação Proteica; Relação Estrutura-Atividade

Palavras-chave

Acinetobacter baumannii; ATP-dependent ligase; MurE; cell wall peptidoglycan biosynthesis; crystal structure

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeo Sintases / Acinetobacter baumannii Idioma: En Revista: FEBS Lett Ano de publicação: 2021 Tipo de documento: Article

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