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Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting.
Kontos, Christos; El Bounkari, Omar; Krammer, Christine; Sinitski, Dzmitry; Hille, Kathleen; Zan, Chunfang; Yan, Guangyao; Wang, Sijia; Gao, Ying; Brandhofer, Markus; Megens, Remco T A; Hoffmann, Adrian; Pauli, Jessica; Asare, Yaw; Gerra, Simona; Bourilhon, Priscila; Leng, Lin; Eckstein, Hans-Henning; Kempf, Wolfgang E; Pelisek, Jaroslav; Gokce, Ozgun; Maegdefessel, Lars; Bucala, Richard; Dichgans, Martin; Weber, Christian; Kapurniotu, Aphrodite; Bernhagen, Jürgen.
Afiliação
  • Kontos C; Division of Peptide Biochemistry, TUM School of Life Sciences, Technische Universität München (TUM), 85354, Freising, Germany.
  • El Bounkari O; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 81377, Munich, Germany.
  • Krammer C; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 81377, Munich, Germany.
  • Sinitski D; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 81377, Munich, Germany.
  • Hille K; Division of Peptide Biochemistry, TUM School of Life Sciences, Technische Universität München (TUM), 85354, Freising, Germany.
  • Zan C; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 81377, Munich, Germany.
  • Yan G; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 81377, Munich, Germany.
  • Wang S; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 81377, Munich, Germany.
  • Gao Y; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 81377, Munich, Germany.
  • Brandhofer M; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 81377, Munich, Germany.
  • Megens RTA; Institute for Cardiovascular Prevention, Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 80336, Munich, Germany.
  • Hoffmann A; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 81377, Munich, Germany.
  • Pauli J; Department of Anaesthesiology, Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 81377, Munich, Germany.
  • Asare Y; Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technische Universität München (TUM), 81675, Munich, Germany.
  • Gerra S; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 81377, Munich, Germany.
  • Bourilhon P; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 81377, Munich, Germany.
  • Leng L; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 81377, Munich, Germany.
  • Eckstein HH; Yale University School of Medicine, New Haven, CT, 06510, USA.
  • Kempf WE; Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technische Universität München (TUM), 81675, Munich, Germany.
  • Pelisek J; Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technische Universität München (TUM), 81675, Munich, Germany.
  • Gokce O; Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technische Universität München (TUM), 81675, Munich, Germany.
  • Maegdefessel L; Department of Vascular Surgery, University Hospital Zurich, 8091, Zurich, Switzerland.
  • Bucala R; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 81377, Munich, Germany.
  • Dichgans M; Munich Cluster for Systems Neurology (SyNergy), 81377, Munich, Germany.
  • Weber C; Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technische Universität München (TUM), 81675, Munich, Germany.
  • Kapurniotu A; Yale University School of Medicine, New Haven, CT, 06510, USA.
  • Bernhagen J; Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians-Universität (LMU) München, 81377, Munich, Germany.
Nat Commun ; 11(1): 5981, 2020 11 25.
Article em En | MEDLINE | ID: mdl-33239628
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Fatores Inibidores da Migração de Macrófagos / Oxirredutases Intramoleculares / Receptores CXCR4 / Aterosclerose Tipo de estudo: Prognostic_studies Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Fatores Inibidores da Migração de Macrófagos / Oxirredutases Intramoleculares / Receptores CXCR4 / Aterosclerose Tipo de estudo: Prognostic_studies Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha