The role of ERα36 in cell type-specific functions of estrogen and cancer development.
Pharmacol Res
; 163: 105307, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-33246174
ABSTRACT
Exploring the regulatory effects of estrogen on different body organs via its receptors is largely of interest. Recently, the expression, signaling and the clinical significance of ERα36, the newly identified isoform of ERα, mediating non-genomic signaling of estrogen, have been studied in a wide range of organs and tumors. ERα36 is expressed highly in the CNS and actively involved in neuroprotection. It is also suggested to be an important estrogen receptor involved in preserving bone in postmenopausal women. On the oncological side, although ERα36 has usually been considered to be an oncogenic molecule, results from some studies paradoxically imply its protective role in certain tumors. Collectively, it seems that ERα36 is highly involved in cell type-specific functions of estrogen through its MAPK/ERK signaling, which is dependent on ERα36 expression levels, ligand concentrations and disease stage. The response is also dependent on the levels of ERα66 and ERß. These factors influence the ERK kinetic and determine the ultimate mitogenic or antimitogenic signaling of estrogen, leading to cell survival or cell death. In this review, we summarize the recent organ-specific, cellular and molecular events and the mechanisms involved in estrogen effects mediated through the ERα36/ ERα66 with a particular focus on carcinomas where more clinical information has recently emerged.
Palavras-chave
Broussoflavonol B (PubChem CID: 480828); Cancer; Cyanidin-3-o-glucoside (PubChem CID: 441667); Decitabine (CID: 451668); ERK kinetic; ERα36; ERα66; Epigallocatechin-gallate (PubChem CID: 65064); Estradiol (PubChem CID: 5757); Estrogen receptor; Fulvestrant (PubChem CID: 104741); Icaritin (CID: 5318980); Letrozole (PubChem CID: 3902); Paclitaxel (PubChem CID: 36314); Tamoxifen (PubChem CID: 2733526); Tamoxifen resistance
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Estrogênio
/
Estrogênios
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Pharmacol Res
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article