[Correlation of serum PTTG1 expression level with clinicopathological features and prognosis in patients with laryngeal cancer].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 34(12): 1128-1131, 2020 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-33254350
ABSTRACT
Objective:
To investigate the correlation between the expression level of serum pituitary tumor transforming geneï¼PTTG1ï¼ and clinicopathological characteristics and prognosis in patients with laryngeal cancer.Method:
Enzyme-linked immunosorbent assay was used to detect the expression of serum PTTG1 in 80 patients with laryngeal cancer and 60 patients with vocal cord polyps. The relationship between the clinicopathological characteristics of patients with laryngeal cancer and the expression of serum PTTG1 was analyzed. Cox regression analysis was used to analyze related factors affecting the prognosis of laryngeal cancer.Result:
Serum PTTG1 expression level in patients with laryngeal cancer was significantly higher than that in patients with vocal cord polyps, and the difference was statistically significantï¼P<0.05ï¼. The higher the lymph node metastasis, the higher the tumor TNM stage, and the lower the degree of differentiation, the higher the serum PTTG1 expression levelï¼P<0.05ï¼. In the prognostic survival analysis, univariate analysis showed that lymph node metastasis, tumor TNM stage, degree of differentiation, tumor diameter, and expression of PTTG1 were related to the prognosis of laryngeal cancerï¼P<0.01ï¼. Cox regression multivariate showed lymph node metastasisï¼HR=2.651, 95%CI1.452-4.823, P=0.002ï¼, high tumor TNM stageï¼HR=2.944, 95%CI1.155-6.189, P=0.026ï¼, and low differentiationï¼HR=1.620, 95%CI1.133-2.169, P=0.003ï¼ and high PTTG1 expressionï¼HR=3.511, 95%CI1.432-7.156, P<0.001ï¼ were risk factors affecting the prognosis of patients with laryngeal cancer.Conclusion:
The expression level of serum PTTG1 may be closely related to the clinicopathological characteristics and prognosis of patients with laryngeal cancer, and its high expression may be one of the indicators of poor prognosis of patients with laryngeal cancer.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Laríngeas
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
Zh
Revista:
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Ano de publicação:
2020
Tipo de documento:
Article