Linoleic Acid Status in Cell Membranes Inversely Relates to the Prevalence of Symptomatic Carotid Artery Disease.
Stroke
; 52(2): 703-706, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-33272124
ABSTRACT
BACKGROUND AND PURPOSE:
The red blood cell fatty acid composition objectively reflects the long-term dietary intake of several fatty acids. In patients undergoing carotid endarterectomy, we explored whether red blood cell status of selected fatty acids related to symptomatic carotid artery disease.METHODS:
We included patients with symptomatic (n=22) and asymptomatic (n=23) carotid artery disease. We determined all-C181 trans, linoleic acid (LA, C182n6), alpha-linolenic acid (C183n3), and the omega-3 index (sum of eicosapentaenoic [C205n3] and docosahexaenoic [C226n3] acids) in both red blood cells and carotid plaque phospholipids by gas-chromatography.RESULTS:
In a multivariate logistic regression analysis, we only observed a significant association for LA, whose red blood cell status was inversely related to symptomatic carotid artery disease (odds ratio, 0.116 [95% CI, 0.022-0.607], P=0.011, for each 1-SD increase). A similar result was observed for LA in carotid plaque phospholipids.CONCLUSIONS:
Cell membrane enrichment in LA, which reflects its intake, was inversely related to symptomatic carotid disease. This increases evidence supporting a favorable role of dietary LA in vascular health.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças das Artérias Carótidas
/
Ácido Linoleico
/
Membrana Eritrocítica
Tipo de estudo:
Diagnostic_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Stroke
Ano de publicação:
2021
Tipo de documento:
Article