Spreading of Isolated <i>Ptch</i> Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice.

Brandes, Nadine; Mitkovska, Slavica Hristomanova; Botermann, Dominik Simon; Maurer, Wiebke; Müllen, Anna; Scheile, Hanna; Zabel, Sebastian; Frommhold, Anke; Heß, Ina; Hahn, Heidi; Uhmann, Anja

Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice.

Brandes, Nadine; Mitkovska, Slavica Hristomanova; Botermann, Dominik Simon; Maurer, Wiebke; Müllen, Anna; Scheile, Hanna; Zabel, Sebastian; Frommhold, Anke; Heß, Ina; Hahn, Heidi; Uhmann, Anja.

Afiliação

Brandes N; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Mitkovska SH; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Botermann DS; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Maurer W; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Müllen A; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Scheile H; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Zabel S; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Frommhold A; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Heß I; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Hahn H; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.
Uhmann A; Tumor Genetics Group, Institute of Human Genetics, University Medical Center Göttingen, Heinrich-Düker-Weg 12, 37079 Göttingen, Germany.

Int J Mol Sci ; 21(23)2020 Dec 05.

Article em En | MEDLINE | ID: mdl-33291515

Assuntos

Carcinoma Basocelular/genética; Carcinoma Basocelular/patologia; Transformação Celular Neoplásica/genética; Mutação; Receptor Patched-1/genética; Fatores Etários; Animais; Carcinoma Basocelular/metabolismo; Suscetibilidade a Doenças; Células Epidérmicas/metabolismo; Células Epidérmicas/patologia; Imunofluorescência; Técnicas de Introdução de Genes; Genes Reporter; Folículo Piloso/metabolismo; Folículo Piloso/patologia; Humanos; Imuno-Histoquímica; Imunofenotipagem; Camundongos; Camundongos Transgênicos; Receptor Patched-1/metabolismo; Pele/metabolismo; Pele/patologia; Neoplasias Cutâneas/genética; Neoplasias Cutâneas/metabolismo; Células-Tronco/metabolismo; Células-Tronco/patologia

Palavras-chave

Patched receptor; basal cell carcinoma; epidermal cells; epidermis; hair follicle; keratin 5

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Basocelular / Transformação Celular Neoplásica / Receptor Patched-1 / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha

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