A Second-Generation Fungerp Analog, SCY-247, Shows Potent <i>In Vivo</i> Activity in a Murine Model of Hematogenously Disseminated Candida albicans.

Chu, Sherman; Long, Lisa; McCormick, Thomas S; Borroto-Esoda, Katyna; Barat, Stephen; Ghannoum, Mahmoud A

A Second-Generation Fungerp Analog, SCY-247, Shows Potent In Vivo Activity in a Murine Model of Hematogenously Disseminated Candida albicans.

Chu, Sherman; Long, Lisa; McCormick, Thomas S; Borroto-Esoda, Katyna; Barat, Stephen; Ghannoum, Mahmoud A.

Afiliação

Chu S; Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.
Long L; College of Osteopathic Medicine of the Pacific-Northwest (COMP), Lebanon, Oregon, USA.
McCormick TS; Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.
Borroto-Esoda K; Center for Medical Mycology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Barat S; Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.
Ghannoum MA; Scynexis Inc., Jersey City, New Jersey, USA.

Antimicrob Agents Chemother ; 65(3)2021 02 17.

Article em En | MEDLINE | ID: mdl-33318003

Assuntos

Candida albicans; Candidíase; Animais; Antifúngicos/uso terapêutico; Candidíase/tratamento farmacológico; Modelos Animais de Doenças; Glicosídeos; Camundongos; Testes de Sensibilidade Microbiana

Palavras-chave

SCY-247; candidiasis; fungerp; ibrexafungerp; triterpenoid class; ß-(1,3)-d-glucan

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candida albicans / Candidíase Limite: Animals Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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