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Prevalence and intensity of soil-transmitted helminth infections of children in sub-Saharan Africa, 2000-18: a geospatial analysis.
Sartorius, Benn; Cano, Jorge; Simpson, Hope; Tusting, Lucy S; Marczak, Laurie B; Miller-Petrie, Molly K; Kinvi, Boniface; Zoure, Honorat; Mwinzi, Pauline; Hay, Simon I; Rebollo, Maria; Pullan, Rachel L.
Afiliação
  • Sartorius B; Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK; Department of Health Metrics Sciences, University of Washington, Seattle, WA, USA; Department of Public Health Medicine, University of KwaZulu-Natal, Durban, South Africa. Electronic address: benn.sartorius1@l
  • Cano J; Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK; Expanded Special Project for Elimination of Neglected Tropical Diseases, WHO Regional Office for Africa, Brazzaville, Democratic Republic of the Congo.
  • Simpson H; Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK.
  • Tusting LS; Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK; Centre on Climate Change and Planetary Health, London School of Hygiene and Tropical Medicine, London, UK.
  • Marczak LB; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
  • Miller-Petrie MK; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
  • Kinvi B; Expanded Special Project for Elimination of Neglected Tropical Diseases, WHO Regional Office for Africa, Brazzaville, Democratic Republic of the Congo.
  • Zoure H; Expanded Special Project for Elimination of Neglected Tropical Diseases, WHO Regional Office for Africa, Brazzaville, Democratic Republic of the Congo.
  • Mwinzi P; Expanded Special Project for Elimination of Neglected Tropical Diseases, WHO Regional Office for Africa, Brazzaville, Democratic Republic of the Congo.
  • Hay SI; Department of Health Metrics Sciences, University of Washington, Seattle, WA, USA; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
  • Rebollo M; Expanded Special Project for Elimination of Neglected Tropical Diseases, WHO Regional Office for Africa, Brazzaville, Democratic Republic of the Congo.
  • Pullan RL; Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK.
Lancet Glob Health ; 9(1): e52-e60, 2021 01.
Article em En | MEDLINE | ID: mdl-33338459
BACKGROUND: Driven by global targets to eliminate soil-transmitted helminths as a public health problem, governments have rapidly rolled out control programmes using school and community-based platforms. To justify and target ongoing investment, quantification of impact and identification of remaining high-risk areas are needed. We aimed to assess regional progress towards these targets. METHODS: We did a continental-scale ecological analysis using a Bayesian space-time hierarchical model to estimate the effects of known environmental, socioeconomic, and control-related factors on the prevalence of soil-transmitted helminths, and we mapped the probability that implementation units had achieved moderate-to-heavy intensity infection prevalence of less than 2% among children aged 5-14 years between Jan 1, 2000, and Dec 31, 2018. FINDINGS: We incorporated data from 26 304 georeferenced surveys, spanning 3096 (60%) of the 5183 programmatic implementation units. Our findings suggest a reduction in the prevalence of soil-transmitted helminths in children aged 5-14 years in sub-Saharan Africa, from 44% in 2000 to 13% in 2018, driven by sustained delivery of preventive chemotherapy, improved sanitation, and economic development. Nevertheless, 1301 (25%) of 5183 implementation units still had an estimated prevalence of moderate-to-heavy intensity infection exceeding the 2% target threshold in 2018, largely concentrated in nine countries (in 1026 [79%] of 1301 implementation units): Nigeria, Democratic Republic of the Congo, Ethiopia, Cameroon, Angola, Mozambique, Madagascar, Equatorial Guinea, and Gabon. INTERPRETATION: Our estimates highlight the areas to target and strengthen interventions, and the areas where data gaps remain. If elimination of soil-transmitted helminths as a public health problem is to be achieved in sub-Saharan Africa by 2030, continued investment in treatment and prevention activities are essential to ensure that no areas are left behind. FUNDING: Bill & Melinda Gates Foundation.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Solo / Análise Espacial / Helmintíase Tipo de estudo: Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Animals / Child / Child, preschool / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Lancet Glob Health Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Solo / Análise Espacial / Helmintíase Tipo de estudo: Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Animals / Child / Child, preschool / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Lancet Glob Health Ano de publicação: 2021 Tipo de documento: Article