Conventional Ultrafiltration During Elective Cardiac Surgery and Postoperative Acute Kidney Injury.
J Cardiothorac Vasc Anesth
; 35(5): 1310-1318, 2021 May.
Article
em En
| MEDLINE
| ID: mdl-33339661
ABSTRACT
OBJECTIVE:
Conventional ultrafiltration (CUF) during cardiopulmonary bypass (CPB) serves to hemoconcentrate blood volume to avoid allogeneic blood transfusions. Previous studies have determined CUF volumes as a continuous variable are associated with postoperative acute kidney injury (AKI) after cardiac surgery, but optimal weight-indexed volumes that predict AKI have not been described.DESIGN:
Retrospective cohort.SETTING:
Single-center university hospital.PARTICIPANTS:
A total of 1,641 consecutive patients who underwent elective cardiac surgery between June 2013 and December 2015.INTERVENTIONS:
The CUF volume was removed during CPB in all participants as part of routine practice. The authors investigated the association of dichotomized weight-indexed CUF volume removal with postoperative AKI development to provide pragmatic guidance for clinical practice at the authors' institution. MEASUREMENTS AND MAINRESULTS:
Primary outcomes of postoperative AKI were defined by the Kidney Disease Improving Global Outcomes staging criteria and dichotomized, weight-indexed CUF volumes (mL/kg) were defined by (1) extreme quartiles (CONCLUSIONS:
Removal of weight-indexed CUF volumes > 32 mL/kg increased the risk for postoperative AKI development. Importantly, CUF volume removal of any amount did not mitigate allogeneic blood transfusion during elective cardiac surgery. Prospective studies are needed to validate these findings.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Injúria Renal Aguda
/
Procedimentos Cirúrgicos Cardíacos
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Cardiothorac Vasc Anesth
Assunto da revista:
ANESTESIOLOGIA
/
CARDIOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article