Vascular Tumor Recapitulated in Endothelial Cells from hiPSCs Engineered to Express the <i>SERPINE1-FOSB</i> Translocation.

van IJzendoorn, David G P; Salvatori, Daniela C F; Cao, Xu; van den Hil, Francijna; Briaire-de Bruijn, Inge H; de Jong, Danielle; Mei, Hailiang; Mummery, Christine L; Szuhai, Karoly; Bovée, Judith V M G; Orlova, Valeria V

Vascular Tumor Recapitulated in Endothelial Cells from hiPSCs Engineered to Express the SERPINE1-FOSB Translocation.

van IJzendoorn, David G P; Salvatori, Daniela C F; Cao, Xu; van den Hil, Francijna; Briaire-de Bruijn, Inge H; de Jong, Danielle; Mei, Hailiang; Mummery, Christine L; Szuhai, Karoly; Bovée, Judith V M G; Orlova, Valeria V.

Afiliação

van IJzendoorn DGP; Department of Pathology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Salvatori DCF; Central Laboratory Animal Facility, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Cao X; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
van den Hil F; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Briaire-de Bruijn IH; Department of Pathology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
de Jong D; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Mei H; Sequencing Analysis Support Core, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Mummery CL; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Szuhai K; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Bovée JVMG; Department of Pathology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Orlova VV; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.

Cell Rep Med ; 1(9): 100153, 2020 12 22.

Article em En | MEDLINE | ID: mdl-33377124

Assuntos

Células Endoteliais/metabolismo; Células-Tronco Pluripotentes Induzidas/metabolismo; Inibidor 1 de Ativador de Plasminogênio/metabolismo; Proteínas Proto-Oncogênicas c-fos/metabolismo; Diferenciação Celular/fisiologia; Humanos; Neoplasias de Tecido Vascular/metabolismo; Proteínas Proto-Oncogênicas c-fos/genética; Neoplasias de Tecidos Moles/metabolismo; Translocação Genética/fisiologia; Neoplasias Vasculares/metabolismo

Palavras-chave

CRISPR/Cas9-mediated gene targeting; PHE; chromosomal translocation; endothelial cell differentiation; gene fusion; hiPSC-ECs; hiPSC-derived ECs; hiPSCs; human induced pluripotent stem cells; pseudomyogenic hemangioendothelioma; t(7;19)(q22;q13) SERPINE1-FOSB chromosomal translocation; tumor model; vascular tumor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-fos / Inibidor 1 de Ativador de Plasminogênio / Células Endoteliais / Células-Tronco Pluripotentes Induzidas Limite: Humans Idioma: En Revista: Cell Rep Med Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda

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