Population model analysis of chiral inversion and degradation of bupropion enantiomers, and application to enantiomer specific fraction unbound determination in rat plasma and brain.

Bhattacharya, Chandrali; Masters, Andrea R; Bach, Christine; Stratford, Robert E

Bhattacharya, Chandrali; Masters, Andrea R; Bach, Christine; Stratford, Robert E.

Afiliação

Bhattacharya C; Department of Pharmacy Practice, Purdue University, Indianapolis, IN, 46202, United States.
Masters AR; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Clinical Pharmacology Analytical Core, Indianapolis, IN, 46202, United States.
Bach C; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Clinical Pharmacology Analytical Core, Indianapolis, IN, 46202, United States.
Stratford RE; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, United States. Electronic address: robstrat@iu.edu.

J Pharm Biomed Anal ; 195: 113872, 2021 Feb 20.

Article em En | MEDLINE | ID: mdl-33388643

Assuntos

Bupropiona; Preparações Farmacêuticas; Animais; Encéfalo; Cinética; Ratos; Estereoisomerismo

Palavras-chave

Bioanalysis; Bupropion; Chiral inversion; In vitro model; Kinetics; Pharmacokinetic modeling; Protein binding

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Bupropiona Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Pharm Biomed Anal Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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