LINC00324 facilitates cell proliferation through competing for miR2145p in immature ovarian teratocarcinoma.
Int J Mol Med
; 47(1): 397-407, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-33416104
ABSTRACT
Immature ovarian teratocarcinoma (IOT) is a rare and malignant type of ovarian teratoma, and the molecular mechanisms underlying the pathogenesis and malignant phenotype of IOT remain uncharacterized. The present study examined a long noncoding RNA (lncRNA), longchain intergenic noncoding RNA324 (LINC00324), which may serve a crucial role in pathogenesis of IOT. According to the results, LINC00324 was upregulated in IOT tissues and cells, as determined by reverse transcriptionquantitative PCR, and its depletion impaired cell proliferation ability and improved cell apoptosis ability in IOT. Furthermore, LINC00324 acted as a miR2145p sponge to derepress cyclin dependent kinase 6 (CDK6), cyclin D1 (CCND1), murine double minute homolog 2 (MDM2), and mouse double minute 4 (MDM4) expression, thus increasing IOT cell proliferation and repressing apoptosis. Taken together, these results demonstrated that LINC00324 could serve as a competing endogenous RNA to facilitate IOT cell proliferation by regulation of miR2145pCDK6/CCND1/MDM2/MDM4 network, which possibly provide a novel therapeutic target for IOT.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
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Teratocarcinoma
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MicroRNAs
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Proliferação de Células
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RNA Longo não Codificante
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
Idioma:
En
Revista:
Int J Mol Med
Assunto da revista:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Ano de publicação:
2021
Tipo de documento:
Article