Acquired deficiency of peroxisomal dicarboxylic acid catabolism is a metabolic vulnerability in hepatoblastoma.

Wang, Huabo; Lu, Jie; Chen, Xiaoguang; Schwalbe, Marie; Gorka, Joanna E; Mandel, Jordan A; Wang, Jinglin; Goetzman, Eric S; Ranganathan, Sarangarajan; Dobrowolski, Steven F; Prochownik, Edward V

Wang, Huabo; Lu, Jie; Chen, Xiaoguang; Schwalbe, Marie; Gorka, Joanna E; Mandel, Jordan A; Wang, Jinglin; Goetzman, Eric S; Ranganathan, Sarangarajan; Dobrowolski, Steven F; Prochownik, Edward V.

Afiliação

Wang H; Division of Hematology/Oncology, Department of Pediatrics UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lu J; Division of Hematology/Oncology, Department of Pediatrics UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Chen X; Division of Hematology/Oncology, Department of Pediatrics UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA; School of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan, People's Republic of China.
Schwalbe M; Division of Hematology/Oncology, Department of Pediatrics UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Gorka JE; Division of Hematology/Oncology, Department of Pediatrics UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Mandel JA; Division of Hematology/Oncology, Department of Pediatrics UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Wang J; Division of Hematology/Oncology, Department of Pediatrics UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA; Central South University Xiangya School of Medicine, Changsha, Hunan, People's Republic of China.
Goetzman ES; Division of Medical Genetics, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ranganathan S; Department of Pathology, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.
Dobrowolski SF; Division of Medical Genetics, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Prochownik EV; Division of Hematology/Oncology, Department of Pediatrics UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA; The Hillman Cancer Center, The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; The Pittsburgh Liver Research Institute, Pittsburgh, Pennsylvania, U

J Biol Chem ; 296: 100283, 2021.

Article em En | MEDLINE | ID: mdl-33450224

Assuntos

Ácidos Graxos/metabolismo; Hepatoblastoma/metabolismo; Neoplasias Hepáticas/metabolismo; Enzima Bifuncional do Peroxissomo/genética; Animais; Ácidos Dicarboxílicos/efeitos adversos; Ácidos Dicarboxílicos/farmacologia; Ácidos Graxos/genética; Hepatoblastoma/genética; Hepatoblastoma/patologia; Humanos; Fígado/enzimologia; Fígado/metabolismo; Fígado/patologia; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/patologia; Metabolismo/genética; Camundongos; Camundongos Knockout; Mitocôndrias/genética; Mitocôndrias/metabolismo; Oxirredução; Peroxissomos/genética; Peroxissomos/metabolismo

Palavras-chave

Ehhadh; Warburg effect; cancer metabolism; fatty acid oxidation; hepatocellular carcinoma; metabolic reprogramming; oxidative phosphorylation; peroxisome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatoblastoma / Ácidos Graxos / Enzima Bifuncional do Peroxissomo / Neoplasias Hepáticas Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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