The epithelial-mesenchymal transition phenotype is associated with the frequency of tumor spread through air spaces (STAS) and a High risk of recurrence after resection of lung carcinoma.
Lung Cancer
; 153: 49-55, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33454517
ABSTRACT
OBJECTIVES:
The prognostic value of spread through air spaces (STAS) in lung carcinoma has been validated in independent cohorts. Epithelial-mesenchymal transition (EMT) is a biological process that promotes the migration and invasiveness of tumor cells. To investigate the role of the EMT phenotype in the occurrence of STAS, we analyzed patients with therapy-naive lung adenocarcinoma and squamous cell carcinoma undergoing lobectomy (nâ¯=â¯635). MATERIALS ANDMETHODS:
STAS was defined by the presence of tumor cells within air spaces in the lung parenchyma beyond the edge of the main tumor. The expression of E-cadherin, vimentin, and ®-catenin was evaluated by immunohistochemistry using tissue microarray. Tumors were classified into three EMT phenotypes (epithelial, intermediate, and mesenchymal). Recurrence-free probability and overall survival were analyzed using the log-rank test and the Cox proportional hazards model.RESULTS:
STAS was less frequently observed in tumors with epithelial phenotype than in those with non-epithelial phenotype (pâ¯=â¯0.034), and more frequent in patients with nuclear ß-catenin-positive tumors (pâ¯<â¯0.001). The EMT phenotype was an independent prognostic factor of recurrence (mesenchymal vs. epithelial hazard ratio [HR]â¯=â¯2.27, pâ¯=â¯0.014; mesenchymal vs. intermediate HRâ¯=â¯2.13, pâ¯=â¯0.019).CONCLUSION:
We have demonstrated that in patients with resected lung carcinoma, STAS was less frequent in tumors with an epithelial phenotype than in those with non-epithelial phenotype, and that the nuclear translocation of ß-catenin was associated with a higher rate of STAS. The mesenchymal state was an independent predictor of high risk of recurrence in patients with STAS.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenocarcinoma de Pulmão
/
Neoplasias Pulmonares
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Lung Cancer
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Japão