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Simulating Nanomaterial Transformation in Cascaded Biological Compartments to Enhance the Physiological Relevance of In Vitro Dosing Regimes: Optional or Required?
Llewellyn, Samantha V; Kämpfer, Angela; Keller, Johannes G; Vilsmeier, Klaus; Büttner, Veronika; Ag Seleci, Didem; Schins, Roel P F; Doak, Shareen H; Wohlleben, Wendel.
Afiliação
  • Llewellyn SV; In vitro Toxicology Group, Institute of Life Science, Swansea University Medical School, Swansea University, Singleton Park, Swansea, Wales, SA2 8PP, UK.
  • Kämpfer A; IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, Düsseldorf, 40225, Germany.
  • Keller JG; Advanced Materials Research, Department of Material Physics and Analytics and Department of Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, 67056, Germany.
  • Vilsmeier K; Advanced Materials Research, Department of Material Physics and Analytics and Department of Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, 67056, Germany.
  • Büttner V; IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, Düsseldorf, 40225, Germany.
  • Ag Seleci D; Advanced Materials Research, Department of Material Physics and Analytics and Department of Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, 67056, Germany.
  • Schins RPF; IUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, Düsseldorf, 40225, Germany.
  • Doak SH; In vitro Toxicology Group, Institute of Life Science, Swansea University Medical School, Swansea University, Singleton Park, Swansea, Wales, SA2 8PP, UK.
  • Wohlleben W; Advanced Materials Research, Department of Material Physics and Analytics and Department of Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, 67056, Germany.
Small ; 17(15): e2004630, 2021 04.
Article em En | MEDLINE | ID: mdl-33475244
ABSTRACT
Would an engineered nanomaterial (ENM) still have the same identity once it reaches a secondary target tissue after a journey through several physiological compartments? Probably not. Does it matter? ENM pre-treatments may enhance the physiological relevance of in vitro testing via controlled transformation of the ENM identity. The implications of material transformation upon reactivity, cytotoxicity, inflammatory, and genotoxic potential of Ag and SiO2 ENM on advanced gastro-intestinal tract cell cultures and 3D liver spheroids are demonstrated. Pre-treatments are recommended for certain ENM only.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dióxido de Silício / Nanoestruturas Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dióxido de Silício / Nanoestruturas Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido