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The neuropeptide allatostatin C from clock-associated DN1p neurons generates the circadian rhythm for oogenesis.
Zhang, Chen; Daubnerova, Ivana; Jang, Yong-Hoon; Kondo, Shu; Zitnan, Dusan; Kim, Young-Joon.
Afiliação
  • Zhang C; School of Life Sciences, Gwangju Institute of Science and Technology, 61005 Gwangju, Republic of Korea.
  • Daubnerova I; School of Life Sciences, Gwangju Institute of Science and Technology, 61005 Gwangju, Republic of Korea.
  • Jang YH; Institute of Zoology, Slovak Academy of Sciences, 84506 Bratislava, Slovakia.
  • Kondo S; School of Life Sciences, Gwangju Institute of Science and Technology, 61005 Gwangju, Republic of Korea.
  • Zitnan D; Invertebrate Genetics Laboratory, National Institute of Genetics, 411-8540 Shizuoka, Japan.
  • Kim YJ; Institute of Zoology, Slovak Academy of Sciences, 84506 Bratislava, Slovakia.
Proc Natl Acad Sci U S A ; 118(4)2021 01 26.
Article em En | MEDLINE | ID: mdl-33479181
ABSTRACT
The link between the biological clock and reproduction is evident in most metazoans. The fruit fly Drosophila melanogaster, a key model organism in the field of chronobiology because of its well-defined networks of molecular clock genes and pacemaker neurons in the brain, shows a pronounced diurnal rhythmicity in oogenesis. Still, it is unclear how the circadian clock generates this reproductive rhythm. A subset of the group of neurons designated "posterior dorsal neuron 1" (DN1p), which are among the ∼150 pacemaker neurons in the fly brain, produces the neuropeptide allatostatin C (AstC-DN1p). Here, we report that six pairs of AstC-DN1p send inhibitory inputs to the brain insulin-producing cells, which express two AstC receptors, star1 and AICR2. Consistent with the roles of insulin/insulin-like signaling in oogenesis, activation of AstC-DN1p suppresses oogenesis through the insulin-producing cells. We show evidence that AstC-DN1p activity plays a role in generating an oogenesis rhythm by regulating juvenile hormone and vitellogenesis indirectly via insulin/insulin-like signaling. AstC is orthologous to the vertebrate neuropeptide somatostatin (SST). Like AstC, SST inhibits gonadotrophin secretion indirectly through gonadotropin-releasing hormone neurons in the hypothalamus. The functional and structural conservation linking the AstC and SST systems suggest an ancient origin for the neural substrates that generate reproductive rhythms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oogênese / Ritmo Circadiano / Proteínas de Drosophila / Drosophila melanogaster / Relógios Circadianos / Neurônios Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oogênese / Ritmo Circadiano / Proteínas de Drosophila / Drosophila melanogaster / Relógios Circadianos / Neurônios Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article