Visual Memory Deficits in Middle-Aged APOEÉ4 Homozygotes Detected Using Unsupervised Cognitive Assessments.
J Alzheimers Dis
; 79(4): 1563-1573, 2021.
Article
em En
| MEDLINE
| ID: mdl-33492293
ABSTRACT
BACKGROUND:
The apolipoprotein E (APOE) É4 allele is associated with dose-response effects on cognitive dysfunction and dementia risk in older adults. However, its effects on cognition in middle-aged adults remains unclear.OBJECTIVE:
We examined effects of É4 heterozygosity and homozygosity on objective and subjective cognition in middle-aged adults enrolled in the Healthy Brain Project (HBP) and in older adults from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study.METHODS:
HBP participants (1,000 non-carriers; 450 É4 heterozygotes; 50 É4 homozygotes) completed unsupervised assessments of the Cogstate Brief Battery (CBB), ratings of subjective cognitive function and provided a saliva sample. AIBL cognitively normal participants (650 non-carriers; 204 É4 heterozygotes; 31 É4 homozygotes) completed in-person assessments of the CBB, ratings of subjective cognitive function and provided a blood sample.RESULTS:
Greater memory impairment was observed in middle-aged É4 homozygotes compared with É4 heterozygotes and non-carriers. When data from middle-aged (HBP) and older (AIBL) adults were pooled, the effect of É4 homozygosity and memory impairment increased with age. In both middle-aged and older adults, É4 heterozygotes did not differ from non-carriers on any measure of objective or subjective cognition.CONCLUSION:
Memory impairment in É4 homozygotes is evident in adults aged 50-60 years, and this can be detected through unsupervised cognitive assessments. The effect of É4 homozygosity increases with older age. APOEÉ4 homozygosity has a negative impact on memory as early as midlife, but due to the subtle magnitude of effect, our findings support the necessity of online platforms in large cohorts to assess these complex relationships.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteína E4
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Transtornos da Memória
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Testes Neuropsicológicos
Tipo de estudo:
Screening_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Alzheimers Dis
Assunto da revista:
GERIATRIA
/
NEUROLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Austrália