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BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
Samelson, Avi J; Tran, Quang Dinh; Robinot, Rémy; Carrau, Lucia; Rezelj, Veronica V; Mac Kain, Alice; Chen, Merissa; Ramadoss, Gokul N; Guo, Xiaoyan; Lim, Shion A; Lui, Irene; Nunez, James; Rockwood, Sarah J; Wang, Jianhui; Liu, Na; Carlson-Stevermer, Jared; Oki, Jennifer; Maures, Travis; Holden, Kevin; Weissman, Jonathan S; Wells, James A; Conklin, Bruce R; TenOever, Benjamin R; Chakrabarti, Lisa A; Vignuzzi, Marco; Tian, Ruilin; Kampmann, Martin.
Afiliação
  • Samelson AJ; Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Tran QD; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA.
  • Robinot R; Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75015 Paris, France.
  • Carrau L; École Doctorale BioSPC, Université de Paris, Sorbonne Paris Cité, 75006 Paris, France.
  • Rezelj VV; Institut Pasteur, CIVIC Group, Virus and Immunity Unit, CNRS UMR 3569, 75015 Paris, France.
  • Mac Kain A; Department of Microbiology, Icahn School of Medicine, New York, NY 10029.
  • Chen M; Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75015 Paris, France.
  • Ramadoss GN; Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75015 Paris, France.
  • Guo X; École Doctorale BioSPC, Université de Paris, Sorbonne Paris Cité, 75006 Paris, France.
  • Lim SA; Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Lui I; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA.
  • Nunez J; Gladstone Institutes, San Francisco, 94158, CA, USA.
  • Rockwood SJ; Biomedical Sciences PhD Program, University of California, San Francisco, CA, USA.
  • Wang J; Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Liu N; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA.
  • Carlson-Stevermer J; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
  • Oki J; Present address: Department of Antibody Engineering, Genentech Inc., South San Francisco, CA, 94080, USA.
  • Maures T; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
  • Holden K; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.
  • Weissman JS; Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.
  • Wells JA; Gladstone Institutes, San Francisco, 94158, CA, USA.
  • Conklin BR; School of Medicine, Southern University of Science and Technology, Shenzhen, China 518055.
  • TenOever BR; School of Medicine, Southern University of Science and Technology, Shenzhen, China 518055.
  • Chakrabarti LA; Synthego Corporation, Redwood City, CA 94063, USA, Department of Biology, Massachusetts Institute of Technology, Cambridge, 02142, USA.
  • Vignuzzi M; Synthego Corporation, Redwood City, CA 94063, USA, Department of Biology, Massachusetts Institute of Technology, Cambridge, 02142, USA.
  • Tian R; Synthego Corporation, Redwood City, CA 94063, USA, Department of Biology, Massachusetts Institute of Technology, Cambridge, 02142, USA.
  • Kampmann M; Synthego Corporation, Redwood City, CA 94063, USA, Department of Biology, Massachusetts Institute of Technology, Cambridge, 02142, USA.
bioRxiv ; 2021 Sep 20.
Article em En | MEDLINE | ID: mdl-33501440
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: BioRxiv Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: BioRxiv Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos