CCR2- and Flt3-Dependent Inflammatory Conventional Type 2 Dendritic Cells Are Necessary for the Induction of Adaptive Immunity by the Human Vaccine Adjuvant System AS01.

Bosteels, Cedric; Fierens, Kaat; De Prijck, Sofie; Van Moorleghem, Justine; Vanheerswynghels, Manon; De Wolf, Caroline; Chalon, Aurélie; Collignon, Catherine; Hammad, Hamida; Didierlaurent, Arnaud M; Lambrecht, Bart N

Bosteels, Cedric; Fierens, Kaat; De Prijck, Sofie; Van Moorleghem, Justine; Vanheerswynghels, Manon; De Wolf, Caroline; Chalon, Aurélie; Collignon, Catherine; Hammad, Hamida; Didierlaurent, Arnaud M; Lambrecht, Bart N.

Afiliação

Bosteels C; Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Fierens K; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
De Prijck S; Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Van Moorleghem J; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Vanheerswynghels M; Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
De Wolf C; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Chalon A; Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Collignon C; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Hammad H; Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Didierlaurent AM; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Lambrecht BN; Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.

Front Immunol ; 11: 606805, 2020.

Article em En | MEDLINE | ID: mdl-33519816

Assuntos

Imunidade Adaptativa/efeitos dos fármacos; Adjuvantes Imunológicos/farmacologia; Células Dendríticas/efeitos dos fármacos; Vacina contra Herpes Zoster/farmacologia; Lipídeo A/análogos & derivados; Receptores CCR2/metabolismo; Saponinas/farmacologia; Proteínas do Envelope Viral/farmacologia; Tirosina Quinase 3 Semelhante a fms/metabolismo; Animais; Linfócitos T CD4-Positivos/efeitos dos fármacos; Linfócitos T CD4-Positivos/imunologia; Linfócitos T CD4-Positivos/metabolismo; Linfócitos T CD8-Positivos/efeitos dos fármacos; Linfócitos T CD8-Positivos/imunologia; Linfócitos T CD8-Positivos/metabolismo; Células Cultivadas; Técnicas de Cocultura; Células Dendríticas/imunologia; Células Dendríticas/metabolismo; Feminino; Imunização; Lipídeo A/farmacologia; Lipossomos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Ovalbumina/farmacologia; Receptores CCR2/genética; Transdução de Sinais; Tirosina Quinase 3 Semelhante a fms/genética

Palavras-chave

AS01; CD64; Fc receptor; MAR-1; adjuvant; dendritic cell; inf-cDC2; vaccine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saponinas / Células Dendríticas / Proteínas do Envelope Viral / Adjuvantes Imunológicos / Tirosina Quinase 3 Semelhante a fms / Vacina contra Herpes Zoster / Receptores CCR2 / Imunidade Adaptativa / Lipídeo A Limite: Animals Idioma: En Revista: Front Immunol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Bélgica

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