Activation of Pyroptosis by Membrane-Anchoring AIE Photosensitizer Design: New Prospect for Photodynamic Cancer Cell Ablation.

Wu, Min; Liu, Xingang; Chen, Huan; Duan, Yukun; Liu, Jingjing; Pan, Yutong; Liu, Bin

Wu, Min; Liu, Xingang; Chen, Huan; Duan, Yukun; Liu, Jingjing; Pan, Yutong; Liu, Bin.

Afiliação

Wu M; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore.
Liu X; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore.
Chen H; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore.
Duan Y; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore.
Liu J; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore.
Pan Y; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore.
Liu B; Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore.

Angew Chem Int Ed Engl ; 60(16): 9093-9098, 2021 04 12.

Article em En | MEDLINE | ID: mdl-33543534

Assuntos

Antineoplásicos/farmacologia; Nitrilas/farmacologia; Fotoquimioterapia; Fármacos Fotossensibilizantes/farmacologia; Piroptose/efeitos dos fármacos; Animais; Antineoplásicos/síntese química; Antineoplásicos/química; Linhagem Celular Tumoral; Membrana Celular/efeitos dos fármacos; Membrana Celular/metabolismo; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Citocinas/metabolismo; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Camundongos; Nitrilas/síntese química; Nitrilas/química; Fármacos Fotossensibilizantes/síntese química; Fármacos Fotossensibilizantes/química; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

aggregation-induced emission; membrane anchoring; photodynamic therapy; photosensitizers; pyroptosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Fármacos Fotossensibilizantes / Piroptose / Antineoplásicos / Nitrilas Limite: Animals / Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Singapura

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