Viral mouse models used to study multiple sclerosis: past and present.
Arch Virol
; 166(4): 1015-1033, 2021 Apr.
Article
em En
| MEDLINE
| ID: mdl-33582855
ABSTRACT
Multiple sclerosis (MS) is a common inflammatory demyelinating disease of the central nervous system. Although the etiology of MS is unknown, genetics and environmental factors, such as infections, play a role. Viral infections of mice have been used as model systems to study this demyelinating disease of humans. Three viruses that have long been studied in this capacity are Theiler's murine encephalomyelitis virus, mouse hepatitis virus, and Semliki Forest virus. This review describes the viruses themselves, the infection process, the disease caused by infection and its accompanying pathology, and the model systems and their usefulness in studying MS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Vírus de RNA
/
Modelos Animais de Doenças
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Esclerose Múltipla
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Revista:
Arch Virol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos