Preliminary assessment of viral metagenome from cancer tissue and blood from patients with lung adenocarcinoma.
J Med Virol
; 93(8): 5126-5133, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-33595122
ABSTRACT
In this study, using a viral metagenomic method, we investigated the composition of virome in blood and cancer tissue samples that were collected from 25 patients with lung adenocarcinoma. Results indicated that virus sequences showing similarity to human pegivirus (HPgV), anellovirus, human endogenous retrovirus (HERV), and polyomavirus were recovered from this cohort. Three different complete genomes of HPgV were acquired from the blood samples and one complete genome of polyomavirus was determined from the cancer tissue sample. Phylogenetic analysis indicated that the three HPgV strains belonged to genotype 3 and the polyomavirus showed the highest sequence identity (99.73%) to trichodysplasia spinulosa-associated polyomavirus. PCR screening results indicated that the three HPgVs were present in 5 out of the 25 blood samples and the polyomavirus only existed in a cancer tissue sample pool. Whether infections with viruses have an association with lung cancer needs further study with a larger size of sampling.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenocarcinoma de Pulmão
/
Viroma
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Neoplasias Pulmonares
Limite:
Humans
Idioma:
En
Revista:
J Med Virol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China