Identification of potential therapeutic target of naringenin in breast cancer stem cells inhibition by bioinformatics and <i>in vitro</i> studies.

Hermawan, Adam; Ikawati, Muthi; Jenie, Riris Istighfari; Khumaira, Annisa; Putri, Herwandhani; Nurhayati, Ika Putri; Angraini, Sonia Meta; Muflikhasari, Haruma Anggraini

Identification of potential therapeutic target of naringenin in breast cancer stem cells inhibition by bioinformatics and in vitro studies.

Hermawan, Adam; Ikawati, Muthi; Jenie, Riris Istighfari; Khumaira, Annisa; Putri, Herwandhani; Nurhayati, Ika Putri; Angraini, Sonia Meta; Muflikhasari, Haruma Anggraini.

Afiliação

Hermawan A; Laboratory of Macromolecular Engineering, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
Ikawati M; Laboratory of Macromolecular Engineering, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
Jenie RI; Laboratory of Macromolecular Engineering, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
Khumaira A; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
Putri H; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
Nurhayati IP; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
Angraini SM; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.
Muflikhasari HA; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara II, 55281 Yogyakarta, Indonesia.

Saudi Pharm J ; 29(1): 12-26, 2021 Jan.

Article em En | MEDLINE | ID: mdl-33603536

Palavras-chave

BCSCs, Breast cancer stem cells; Bioinformatics; Breast cancer stem cells; CSC, Cancer stem cell; DAVID, Database for Annotation, Visualization, and Integrated Discovery; DTPs, Direct target proteins; DXR, Doxorubicin; EGF, Epidermal growth factor; EMT, Epithelial to mesenchymal transition; ERα; FITC, fluorescein isothiocyanate; GO, Gene ontology; ITPs, Indirect target proteins; KEGG, Kyoto Encyclopedia of Genes and Genomes; MET, Metformin; MFP, Mammosphere forming potential; NAR, Naringenin; NMPs, Naringenin-mediated proteins; Naringenin; P53; PE, phycoerythrin; PPI, Protein-protein interaction; PTTN, Potential target of naringenin in inhibition of BCSCs; ROS, Reactive oxygen species; Targeted therapy; q-RT PCR, Quantitative real-time polymerase chain reaction

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Saudi Pharm J Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Indonésia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google